Simultaneous Changes of Spatial Memory and Spine Density after Intrahippocampal Administration of Fibrillar Aβ_1–42 to the Rat Brain

Figure 2

fAβ _1–42-injection induced learning deficit in the Morris water maze test. (a) fAβ _1–42-injection resulted in slower learning during the acquisition phase compared to control group (𝑃=0.013); (b) fAβ _1–42-treated animals swam longer distance than the controls to find the platform (𝑃=0.010). Each value represents the mean (±S.E.M.) (𝑛=12 rats per group).

(a)

(b)