An Integrated Analysis of miRNA, lncRNA, and mRNA Expression Profiles

Table 1

Differentially expressed abundant miRNA species as indicated by the most abundant isomiR and all isomiRs.

miRNA	Chr	Consistent or inconsistent	Fold change (the most)	Fold change (all isomiRs)	Up/down
let-7a-5p	9, 11, 22	Yes	−2.35	−3.24	Down
let-7f-5p	9, X	Yes	−2.54	−2.97	Down
miR-103a-3p	5, 20	Yes	2.33	2.05	Up
miR-146a-5p	5	Yes	7.28	5.52	Up
miR-15a-5p	13	No	−4.85	−3.87	Down
miR-194-5p	1, 11	No	7.26	4.56	Up
miR-200b-3p	1	No	8.56	5.45	Up
miR-23a-3p	19	No	−7.19	−5.02	Down
miR-24-3p	9, 19	No	−4.24	−2.14	Down
miR-27a-3p	19	Yes	−6.61	−6.35	Down
miR-27b-3p	9	Yes	−1.82	−2.61	Down
miR-100-5p	11	Yes	−7.27	−4.88	Down
miR-425-5p	3	No	2.98	2.00	Up

These miRNAs are abundantly expressed in HepG2 and L02 cells. They are the top downregulated and upregulated miRNAs in cancer cells (fold change () >2.0 or <−2.0). Chr indicates the genomic locations of the miRNA genes (pre-miRNAs), including multicopy pre-miRNAs. let-7a-5p is located on chr9 (let-7a-1), 11 (let-7a-2), and 22 (let-7a-3). The term “consistent” indicates that the sequence of the most abundant isomiR is the same as that of the reference miRNA sequence in the miRBase database. The term “most” indicates the most abundant isomiR from a given locus. The term “all isomiRs” indicates total number of isomiRs from a given locus.