Repair of Segmental Load-Bearing Bone Defect by Autologous Mesenchymal Stem Cells and Plasma-Derived Fibrin Impregnated Ceramic Block Results in Early Recovery of Limb Function
Figure 5
Histological sections from the middle segment of the implants three months after implantation (H&E). (a) Abundant new bones were found in TEB. The section reveals new bones (Nb) forming a trabecular network amidst infiltrated cells (Ic) while new compact bone (Nb) was found at the right periphery (40x). (b) Here, the peripheral bone appeared more mature with lamellar and osteon features (O) adjacent to the well-formed intramedullary canal filled with marrow element (Me) (100x). (c) Residual ceramic (Ce) was noted in MIC. Mineral deposits (Mi) (stained red) were seen around the ceramic (40x). (d) The section reveals new bones (Nb) that are undergoing mineralization amidst infiltrated marrow element (Me) (40x). (e) Significant fibrous tissues (Fb) were noted in ALLO. The section reveals new bones (Nb) forming a trabecular network amidst infiltrated cells (Ic) (40x). (f) An intact allograft bone (Allo) (100x).
