Laparoscopic Resection for Rectal Cancer: What Is the Evidence?

Table 2

Long-term outcomes-oncological.

Trial	Type	Surgical method in comparison	Numbers	Median follow-up period (months)	Local recurrence	Neoadjuvant therapy administered	Disease-free survival (months)	Median overall survival (months)
CLASICC; [3]	Multicentre RCT—UK	Open versus laparoscopic assisted	254 (O) versus 127 (L)	62.9 in both arms	NA	Not controlled	67.1 versus 70.8	65.8 versus 82.7
Lujan et al.; [18]	Single centre RCT—Spain	Open versus laparoscopic assisted	103 versus 101	34.1, 32.8	5.3 versus 4.8	77 versus 73, no statistical significance	81.0 versus 84.8	75.3 versus 72.1
Ng et al.; [20]	Single centre RCT—UK	Open versus laparoscopic assisted	142 versus 136	136.6, 124.5	9.3 versus 5.5	Neoadjuvant not included in trial	*	+

∗Trial calculated probability of being disease-free at 15 years, 71.4% versus 79%.
⁺Trial calculated probability of overall survival at 15 years, 51.4% versus 47.4%.