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Animals | Administration | Effects | Reference |
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Tg2576 mice | Drinking Cabernet Sauvignon | Reduced amyloid neuropathology and attenuated spatial memory deterioration. | [30] |
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Tg2576 mice | Fed with GPSE | Reduced oligomerization of A peptide and attenuated cognitive impairments. | [32] |
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APP/PS1 mice | Diet with resveratrol | Reduced the number of activated microglia. | [17] |
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C67BL/6J mice | Diet with trans-resveratrol daily | Reduced serum TNF-α and enhanced cognitive function. | [33] |
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C57Bl/6 mice | Resveratrol in food | (1) Increased microvascular density and decreased number of vacuolar abnormalities. (2) Improved in spatial orientation and memory performance. | [10] |
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C57Bl/6J mice | Resveratrol in food | Increased mitochondrial function, improved aerobic capacity, and enhanced sensorimotor function. | [34] |
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2-month-old male mice | i.p. injection of resveratrol | Activated AMPK in the brain. | [35] |
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Wistar rats, ICV injection of STZ | ICV injection of resveratrol | Increased retention latencies and shorter transfer latencies. | [36] |
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Rats, ICV administration of colchicine | Chronically treated with resveratrol (p.o.) | MDA levels reduced but GSH and AchE activity recovered. | [37] |
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Wistar rats, i.p. injection of STZ | i.p. injection of resveratrol | Modulates cholinergic neurotransmission and consequently improves cognition. | [38] |
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Sprague-Dawley rat | Oral resveratrol | Resveratrol may have positive effects on the expression of BDNF. | [39] |
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Inducible p25 transgenic mice | ICV injection of resveratrol | Reduces neurodegeneration in hippocampus and prevents cognitive decline. | [40] |
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