Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 352083, 12 pages
http://dx.doi.org/10.1155/2014/352083
Research Article

Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer

1Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
2Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
4Division of Gastrointestinal and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
5Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
6Division of General Surgery Medicine, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
7School of Medical and Health Sciences, Fooyin University, Kaohsiung 831, Taiwan
8Department of Medical Research, Fooyin University Hospital, Pingtung 928, Taiwan
9Department of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
10Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
11Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
12Department of Pathology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
13Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
14Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
15Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan

Received 7 February 2014; Revised 11 April 2014; Accepted 11 April 2014; Published 6 May 2014

Academic Editor: An Liu

Copyright © 2014 Ming-Yii Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Sauer, H. Becker, W. Hohenberger et al., “Preoperative versus postoperative chemoradiotherapy for rectal cancer,” New England Journal of Medicine, vol. 351, no. 17, pp. 1731–1810, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. A. B. Benson III, P. F. Engstrom, J. P. Arnoletti et al., “NCCN clinical practice guidelines in oncology, rectal cancer,” Journal of the National Comprehensive Cancer Network, vol. 10, no. 8, pp. 1528–1546, 2012. View at Google Scholar
  3. J. F. Bosset, L. Collette, G. Calais et al., “Chemotherapy with preoperative radiotherapy in rectal cancer,” New England Journal of Medicine, vol. 355, no. 11, pp. 1114–1123, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. J. P. Gérard, T. Conroy, F. Bonnetain et al., “Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203,” Journal of Clinical Oncology, vol. 24, no. 28, pp. 4620–4625, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. J. S. Kim, J. S. Kim, M. J. Cho, W. Yoon, and K. Song, “Comparison of the efficacy of oral capecitabine versus bolus 5-FU in preoperative radiotherapy of locally advanced rectal cancer,” Journal of Korean Medical Science, vol. 21, no. 1, pp. 52–57, 2006. View at Google Scholar · View at Scopus
  6. C. F. Chen, M. Y. Huang, C. J. Huang et al., “A observational study of the efficacy and safety of capecitabine versus bolus infusional 5-fluorouracil in pre-operative chemoradiotherapy for locally advanced rectal cancer,” International Journal of Colorectal Disease, vol. 27, no. 6, pp. 727–736, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. K. L. Baglan, R. C. Frazier, D. Yan, R. R. Huang, A. A. Martinez, and J. M. Robertson, “The dose-volume realationship of acute small bowel toxicity from concurrent 5-FU-based chemotherapy and radiation therapy for rectal cancer,” International Journal of Radiation Oncology Biology Physics, vol. 52, no. 1, pp. 176–183, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. L. M. Tho, M. Glegg, J. Paterson et al., “Acute small bowel toxicity and preoperative chemoradiotherapy for rectal cancer: investigating dose-volume relationships and role for inverse planning,” International Journal of Radiation Oncology Biology Physics, vol. 66, no. 2, pp. 505–513, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. J. S. Welsh, R. R. Patel, M. A. Ritter, P. M. Harari, T. R. Mackie, and M. P. Mehta, “Helical tomotherapy: an innovative technology and approach to radiation therapy,” Technology in Cancer Research and Treatment, vol. 1, no. 4, pp. 311–316, 2002. View at Google Scholar · View at Scopus
  10. P. M. Jhaveri, B. S. Teh, A. C. Paulino et al., “Helical tomotherapy significantly reduces dose to normal tissues when compared to 3D-CRT for locally advanced rectal cancer,” Technology in Cancer Research and Treatment, vol. 8, no. 5, pp. 379–385, 2009. View at Google Scholar · View at Scopus
  11. Y. S. Yeh, M. J. Chen, H. L. Tsai et al., “Transanal inside out rectal resection for ultra-low rectal cancer,” Journal of Investigative Surgery, vol. 25, no. 6, pp. 375–380, 2012. View at Publisher · View at Google Scholar
  12. J. H. Park, S. M. Yoon, C. S. Yu, J. H. Kim, T. W. Kim, and J. C. Kim, “Randomized phase 3 trial comparing preoperative and postoperative chemoradiotherapy with capecitabine for locally advanced rectal cancer,” Cancer, vol. 117, no. 16, pp. 3703–3712, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. J. D. Cox, J. Stetz, and T. F. Pajak, “Toxicity criteria of the radiation therapy oncology group (RTOG) and the European organization for research and treatment of cancer (EORTC),” International Journal of Radiation Oncology Biology Physics, vol. 31, no. 5, pp. 1341–1346, 1995. View at Publisher · View at Google Scholar · View at Scopus
  14. O. Dworak, L. Keilholz, and A. Hoffmann, “Pathological features of rectal cancer after preoperative radiochemotherapy,” International Journal of Colorectal Disease, vol. 12, no. 1, pp. 19–23, 1997. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Krishnan, N. A. Janjan, J. M. Skibber et al., “Phase II study of capecitabine (Xeloda®) and concomitant boost radiotherapy in patients with locally advanced rectal cancer,” International Journal of Radiation Oncology Biology Physics, vol. 66, no. 3, pp. 762–771, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Yerushalmi, E. Idelevich, Y. Dror et al., “Preoperative chemoradiation in rectal cancer: retrospective comparison between capecitabine and continuous infusion of 5-fluorouracil,” Journal of Surgical Oncology, vol. 93, no. 7, pp. 529–533, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Das, E. H. Lin, S. Bhatia et al., “Preoperative chemoradiotherapy with capecitabine versus protracted infusion 5-fluorouracil for rectal cancer: a matched-pair analysis,” International Journal of Radiation Oncology Biology Physics, vol. 66, no. 5, pp. 1378–1383, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. A. De Paoli, S. Chiara, G. Luppi et al., “Capecitabine in combination with preoperative radiation therapy in locally advanced, resectable, rectal cancer: a multicentric phase II study,” Annals of Oncology, vol. 17, no. 2, pp. 246–251, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. I. Craven, A. Crellin, R. Cooper, A. Melcher, P. Byrne, and D. Sebag-Montefiore, “Preoperative radiotherapy combined with 5 days per week capecitabine chemotherapy in locally advanced rectal cancer,” British Journal of Cancer, vol. 97, no. 10, pp. 1333–1337, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. A. F. de Bruin, J. J. Nuyttens, F. T. Ferenschild, A. S. T. Planting, C. Verhoef, and J. H. W. de Wilt, “Preoperative chemoradiation with capecitabine in locally advanced rectal cancer,” Netherlands Journal of Medicine, vol. 66, no. 2, pp. 71–76, 2008. View at Google Scholar · View at Scopus
  21. S. Bazarbashi, M. El-Bassiouni, M. Abdelsalam et al., “A modern regimen of pre-operative concurrent chemo-radiation therapy in locally advanced rectal cancer,” Journal of Surgical Oncology, vol. 98, no. 3, pp. 167–174, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Dunst, J. Debus, V. Rudat et al., “Neoadjuvant capecitabine combined with standard radiotherapy in patients with locally advanced rectal cancer: mature results of a phase II trial,” Strahlentherapie und Onkologie, vol. 184, no. 9, pp. 450–456, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. W. G. Elshazly, M. Farouk, and M. Samy, “Preoperative concomitant radiotherapy with oral capecitabine in advanced rectal cancer within 6 cm from anal verge,” International Journal of Colorectal Disease, vol. 24, no. 4, pp. 401–407, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. A. K. Chan, A. O. Wong, and D. A. Jenken, “Preoperative capecitabine and pelvic radiation in locally advanced rectal cancer—is it equivalent to 5-FU infusion plus leucovorin and radiotherapy?” International Journal of Radiation Oncology Biology Physics, vol. 76, no. 5, pp. 1413–1419, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Jin, H. Meng, G. Zhou et al., “Preoperative radiotherapy combined with capecitabine chemotherapy in Chinese patients with locally advanced rectal cancer,” Journal of Gastrointestinal Surgery, vol. 15, no. 10, pp. 1858–1865, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. J. L. Li, J. F. Ji, Y. Cai et al., “Preoperative concomitant boost intensity-modulated radiotherapy with oral capecitabine in locally advanced mid-low rectal cancer: a phase II trial,” Radiotherapy and Oncology, vol. 102, no. 1, pp. 4–9, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. N. Hüser, C. W. Michalski, M. Erkan et al., “Systematic review and meta-analysis of the role of defunctioning stoma in low rectal cancer surgery,” Annals of Surgery, vol. 248, no. 1, pp. 52–60, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. J. W. Huh, Y. A. Park, and S. K. Sohn, “A diverting stoma is not necessary when performing a handsewn coloanal anastomosis for lower rectal cancer,” Diseases of the Colon and Rectum, vol. 50, no. 7, pp. 1040–1046, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. V. L. Tsikitis, D. W. Larson, V. P. Poola et al., “Postoperative morbidity with diversion after low anterior resection in the era of neoadjuvant therapy: a single institution experience,” Journal of the American College of Surgeons, vol. 209, no. 1, pp. 114–118, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. N. K. Kim, S. H. Baik, J. S. Seong et al., “Oncologic outcomes after neoadjuvant chemoradiation followed by curative resection with tumor-specific mesorectal excision for fixed locally advanced rectal cancer: impact of postirradiated pathologic downstaging on local recurrence and survival,” Annals of Surgery, vol. 244, no. 6, pp. 1024–1030, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Govindarajan, D. Reidy, M. R. Weiser et al., “Recurrence rates and prognostic factors in ypN0 rectal cancer after neoadjuvant chemoradiation and total mesorectal excision,” Annals of Surgical Oncology, vol. 18, no. 13, pp. 3666–3672, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. U. S. Shin, C. S. Yu, J. H. Kim et al., “Mucinous rectal cancer: effectiveness of preoperative chemoradiotherapy and prognosis,” Annals of Surgical Oncology, vol. 18, no. 8, pp. 2232–2239, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. P. Passoni, C. Fiorino, N. Slim et al., “Feasibility of an adaptive strategy in preoperative radiochemotherapy for rectal cancer with image-guided tomotherapy: boosting the dose to the shrinking tumor,” International Journal of Radiation Oncology, Biology, Physics, vol. 87, no. 1, pp. 67–72, 2013. View at Publisher · View at Google Scholar
  34. M. De Ridder, K. Tournel, Y. Van Nieuwenhove et al., “Phase II study of preoperative helical tomotherapy for rectal cancer,” International Journal of Radiation Oncology Biology Physics, vol. 70, no. 3, pp. 728–734, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. H. Birgisson, L. Påhlman, U. Gunnarsson, and B. Glimelius, “Late adverse effects of radiation therapy for rectal cancer-a systematic overview,” Acta Oncologica, vol. 46, no. 4, pp. 504–516, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. T. Holm, T. Singnomklao, L. E. Rutqvist, and B. Cedermark, “Adjuvant preoperative radiotherapy in patients with rectal carcinoma. Adverse effects during long term follow-up of two randomized trials,” Cancer, vol. 78, no. 5, pp. 968–976, 1996. View at Google Scholar
  37. K. C. Peeters, C. J. van de Velde, J. W. Leer et al., “Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients-a Dutch Colorectal Cancer Group Study,” Journal of Clinical Oncology, vol. 23, no. 25, pp. 6199–6206, 2005. View at Publisher · View at Google Scholar · View at Scopus