Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer
Table 3
Pathological stage and response after preoperative chemoradiotherapy in patients with locally advanced rectal cancer.
Case number
(%)
Tumor regression grade (TRG)
Grade 0
2 (5.7)
Grade 1
5 (14.3)
Grade 2
7 (20)
Grade 3
16 (45.7)
Pathological complete response (TRG grade 4)
5 (14.3)
Pathological stage
Stage 1
15 (42.9)
Stage 2
6 (17.1)
Stage 3
9 (25.7)
ypT0-T2N0
Yes
20 (57.1)
No
15 (42.9)
Lymphovascular invasion
Yes
6 (17.1)
No
29 (82.9)
Perineural invasion
Yes
8 (22.9)
No
27 (77.1)
Pathological T stage
Downstaging
21 (60.0)
Stable
14 (40.0)
Progressive
0
Case number
(%)
Pathological N stage (in clinical N1-2 patients)
Downstaging
16 (69.6)
Stable
6 (26.1)
Progressive
1 (4.3)
Correlation between TRG and pathological downstage ()
Major respondera
Minor responderb
T downstaging
Yes
20
1
0.010
No
8
6
ypT0-2N0
Yes
19
1
0.027
No
9
6
Pathologic node metastasis
Yes
5
4
0.055
No
23
3
Lymphovascular invasion
Yes
4
2
0.576
No
24
5
Perineural invasion
Yes
4
4
0.033
No
24
3
N downstaging (in clinical N1-2 patients)
Yes
13
3
0.621
No
5
2
TRG 2, TRG 3, and TRG 4 are recognized as major responders after chemoradiotherapy; TRG 0 and TRG 1 are recognized as minor responders after chemoradiotherapy.