Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer

Table 5

Summary of grade 3 or 4 acute toxicities and perioperative complications in locally advanced rectal cancer patients with capecitabine-based chemoradiotherapy.

Oral capecitabine + RT	Grade 3 or 4 acute toxicities (%)						Perioperative complications (%)
	Overall Gr 3 or 4 toxicities	Diarrhea	Leukopenia	Anemia	Dermatitis	Hand-foot syndrome	Anastomotic leakage or pelvic abscess (after LAR)	Wound complications
Krishnan et al. (2006) [15]	N	2	2^a	2	9	0	2.6	3.9
Kim et al. (2006) [5]	N	11.3	0	0	3.1	6.2	5.3	1.1
Yerushalmi et al. (2006) [16]	14	2.3	0	0	4.7	2.3	N	N
Das et al. (2006) [17]	5.6	4.5	1.1	0	0	0	N	N
De Paoli et al. (2006) [18]	11.3	1.9	3.8	3.8	3.8	3.8	N	N
Craven et al. (2007) [19]	N	4.3	N				N
de Bruin et al. (2008) [20]	5	1.7	0	0	3.3	0	4	N
Bazarbashi et al. (2008) [21]	N	35.5	3.2	3.2	N	0	30.8	37.9
Dunst et al. (2008) [22]	N	7	N		1.1	0	N
Chan et al. (2010) [24]	8.8	8.8	0	0	0	0	N
Park et al. (2011) [12]	15	N	2.8	5.6	2.8	2.8	2.4	0.9
Jin et al. (2011) [25]	8.2	3.3	3.3	0	0	1.6	N	6.8
Li et al. (2012) [26]	14.3	9.5	1.6^a	0	3.2	0	N
The current study (2014)	11.1	11.1	0	0	0	0	10.3	5.7

LARC: locally advanced rectal cancer; CRT: chemoradiotherapy; RT: radiotherapy; Gr: grade; N: not reported; LAR: low anterior resection.
^aNeutropenia.