Role of Lectin-Like Oxidized Low Density Lipoprotein-1 in Fetoplacental Vascular Dysfunction in Preeclampsia

Figure 1

Structure and LOX-1 signaling. LOX-1 has four domains: cytosolic domain (1–34 amino acids), transmembrane domain (amino acids 35–61), neck domain (amino acids 62–143), and CTLD (amino acids 144–263). The LOX-1 activation by different ligand increases phosphorylation of p42/44MAPK and p38MAPK and the expression of gp91phox subunit of NADPH oxidase, causing an increase in reactive oxygen species and a decrease in NO and hence endothelial dysfunction manifested by cell apoptosis, thrombosis, inflammation, and vasoconstriction.