Characterization of Musclin as a New Target for Treatment of Hypertension
Figure 1
Effect of DOCA-salt induced hypertension on the mean blood pressure and the expression of musclin protein. Wistar rats underwent uninephrectomy and received subcutaneous injections of DOCA salt and drinking water supplemented with 1.0% NaCl and 0.2% KCl (DOCA group). The vehicle-sham rats (vehicle) received vehicle injections (1 : 1 mineral oil and propylene glycol) and normal tap water. The mean blood pressure (MBP) was recorded using a noninvasive tail-cuff monitor (a) while the expression of musclin protein (11 kDa) was determined using Western blotting analysis (b). The quantification of the results is indicated as the means with the SE ( per group) in each column shown in the lower panel. ** and *** compared with vehicle-sham group.
