The Association of Toll-Like Receptor 4 Polymorphism with Hepatitis C Virus Infection in Saudi Arabian Patients

Table 2

Genotypic distribution of TLR4 SNPs between healthy control subjects and HCV-infected patients.

SNPs	Genotype/allele distribution	Healthy control subjects	HCV-infected patients	OR (95% CI.)		value
rs4986791	CC	469 (78.1%)	418 (93.0%)	1.0000 (Ref.)
	CT	130 (21.7%)	32 (7.0%)	0.276 (0.184–0.416)	41.90	<0.0001
	TT	1 (0.2%)	0 (0%)	0.374 (0.000–10.803)	0.39	0.531
	C	1068 (89.0%)	868 (96.4%)	1.0000 (Ref.)
	T	132 (11.0%)	32 (3.6%)	0.298 (0.201–0.443)	39.59	<0.0001
	TT + CT versus CC			0.274 (0.182–0.412)	42.50	<0.0001
	TT versus CT + CC			0.444 (0.000–12.805)	0.26	0.609
rs4986790	AA	475 (79.2%)	408 (90.9%)	1.0000 (Ref.)
	AG	123 (20.5%)	41 (9.1%)	0.388 (0.266–0.566)	25.39	<0.0001
	GG	2 (0.3%)	0 (0%)	0.233 (0.000–4.472)	1.05	0.305
	A	1073 (89.4%)	857 (95.4%)	1.0000 (Ref.)
	G	127 (10.6%)	41 (4.6%)	0.404 (0.281–0.581)	25.25	<0.0001
	GG versus AG + AA			0.266 (0.000–5.110)	0.84	0.359
	GG + AG versus AA			0.382 (0.262–0.557)	26.40	<0.0001

Risk allele marked in bold letters.