The Association of Toll-Like Receptor 4 Polymorphism with Hepatitis C Virus Infection in Saudi Arabian Patients

Table 4

Genotypic distribution of TLR4 SNPs in chronic HCV carriers (CHC) compared with both patients with liver cirrhosis (Cirr) and patients with HCC combined.

SNPs	Genotype/allele distribution	Chronic HCV patients	Patients with liver cirrhosis + HCC	OR (95% CI.)		value
rs4986791	CC	332 (94.0%)	86 (89.6%)	1.0000 (Ref.)
	CT	22 (6.0%)	10 (10.4%)	1.755 (0.801–3.844)	2.02	0.155
	TT	0 (0%)	0 (0%)	nan
	C	686 (96.9%)	182 (94.8%)	1.0000 (Ref.)
	T	22 (3.1%)	10 (5.2%)	1.713 (0.797–3.682)	1.94	0.163
	TT + CT versus CC			1.755 (0.801–3.844)	2.02	0.155
	TT versus CT + CC			nan
rs4986790	AA	323 (91.8%)	85 (87.6%)	1.0000 (Ref.)
	AG	29 (8.2%)	12 (12.4%)	1.572 (0.770–3.211)	1.565	0.211
	GG	0 (0%)	0 (0%)	nan
	A	675 (95.9%)	182 (93.8%)	1.0000 (Ref.)
	G	29 (4.1%)	12 (6.2%)	1.535 (0.724–3.203)	1.49	0.222
	GG versus AG + AA			nan
	GG + AG versus AA			1.572 (0.770–3.211)	1.565	0.211

Risk allele marked in bold letters.