Contrast Media Viscosity versus Osmolality in Kidney Injury: Lessons from Animal Studies
Figure 6
Elevated proliferation rate of renal cells following CM administration as assessed by immunofluorescence analysis of the incorporation of bromdesoxyuridine (BrdU; red staining) into proximal tubular cells (indicated by green staining of aquaporin-1; scale bar 100 μm). The BrdU incorporation time was 46 hours, starting 2 h after i.v. injection of either saline (a), iopromide 300 mg I/mL (b), or iodixanol 320 mg I/mL solution (c); CM doses were 4 g I/kg of body mass. Semiquantitative analysis of the BrdU-incorporated cells (d). Reprinted from [58].
