Inhibition of Nitric Oxide Synthase Prevents Muscarinic and Purinergic Functional Changes and Development of Cyclophosphamide-Induced Cystitis in the Rat

Figure 2

Mean contractions to methacholine of isolated urinary bladder strip preparations from control (saline-treated; ●) rats and rats with CYP-induced cystitis (■), pretreated with saline ((a), (d); 𝑛=10 and 12), 4-DAMP ((b), (e); 𝑛=8 and 10) or L-NAME ((c), (f); 𝑛=8 in each group). The left column ((a)–(c)) expresses data as absolute values (mN) and the right column ((d)–(f)) as mN/mg. The vertical bars represent the SEM. ^∗ denotes 𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001.