Differences in Cytotoxic, Genotoxic, and Inflammatory Response of Bronchial and Alveolar Human Lung Epithelial Cells to Pristine and COOH-Functionalized Multiwalled Carbon Nanotubes

Figure 6

Genotoxicity of A549 ((a), (c)) and BEAS-2B ((b), (d)) cells after 24 h exposure to 5, 10, and 40 μg/mL of pristine MWCNTs and to 1, 5, 10, 20, and 40 μg/mL of MWCNT-COOH evaluated by Fpg-comet test. ((a), (b)) Direct DNA damage; ((c), (d)) Oxidative DNA damage. Data represent the means of three independent experiments. Hydrogen peroxide (H₂O₂) 100 μM 30 min exposure was used as positive control. *𝑃≤0.05.

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