MYD88 L265P Mutations Are Correlated with 6q Deletion in Korean Patients with Waldenström Macroglobulinemia
Table 3
Patient characteristics and interphase FISH results according to the presence of MYD88 L265P mutation.
Characteristics
MYD88 L265P (+)
MYD88 L265P (−)
Age 65 years
6/11 (55)
2/5 (40)
0.590
Male sex
9/11 (82)
3/5 (60)
0.350
B symptoms
7/11 (64)
3/5 (60)
0.889
Hyperviscosity
5/11 (46)
1/5 (20)
0.330
Splenomegaly
5/11 (46)
2/5 (40)
0.839
Lymphadenopathy
7/11 (64)
5/5 (100)
0.120
Multiple osteolytic lesions
1/11 (9)
1/5 (20)
0.541
Hemoglobin 11.5 g/dL
10/11 (91)
5/5 (100)
0.486
Platelet 100 109/L
2/11 (18)
2/5 (40)
0.350
Death
2/11 (18)
2/5 (40)
0.350
IgM type monoclonal protein
10/11 (91)
3/5 (60)
0.142
Monoclonal protein (g/dL)
3.56 (0.50–5.43)
2.94 (0.55–9.74)
0.777
PB lymphocytes (106/L)
2233 (807–6100)
1415 (1067–21775)
0.955
BM lymphocytes (%)
45.0 (14.4–93.2)
20.7 (3.0–84.7)
0.234
BM plasma cells (%)
3.7 (0–14.0)
3.2 (0–32.9)
0.691
BM cellularity (%)
85 (25–95)
60 (25–85)
0.093
High lymphocyte burden in BM biopsy†
7/11 (64)
0/5 (0)
0.017
6q21 deletion
6/11 (55)
0/5 (0)
0.037
IGH (14q32) translocation
2/11 (18)
2/5 (40)
0.350
P53 (17p13) deletion
1/11 (9)
0/5 (0)
0.486
1q25 amplification
0/11 (0)
1/5 (20)
0.126
Abnormal karyotype
3/7 (43)
2/5 (40)
0.921
BM: bone marrow; FISH: fluorescence in situ hybridization; Ig: immunoglobulin; PB: peripheral blood.
*
P values were calculated using test for categorical variables and Mann-Whitney test for continuous variables between patients with or without the MYD88 L265P mutation. †BM cellularity ≥ 80% with diffuse lymphocytes infiltration in BM biopsy.
