Research Article

Molecular Profiling and Clinical Outcome of High-Grade Serous Ovarian Cancer Presenting with Low- versus High-Volume Ascites

Figure 1

Gene expression profiling of a discovery cohort reveals an immune gene signature for HGSOC tumors presenting with low-volume ascites. Hierarchical clustering of patient samples based on 198 probes differentially expressed by ≥1.5-fold as determined by a moderated t-test ( ) in tumors associated with high- and low-volume ascites. Each line of the cluster tree shown at the top represents one patient sample. The ascites volume group is indicated by the bar at the bottom and by the line color. Magenta bars on the side indicate probes corresponding to the 20 genes that overlap with genes within the TCGA immunoreactive group and are upregulated in the low-volume ascites group.
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