Molecular Profiling and Clinical Outcome of High-Grade Serous Ovarian Cancer Presenting with Low- versus High-Volume Ascites

Table 1

Gene ontology (GO) categories enriched in the low-volume ascites group.

GO term	GO accession	𝑃 value	Corrected 𝑃 value
Antigen processing and presentation	GO:0019882/GO:0030333	7.56𝐸−10	1.45𝐸−06
Antigen processing and presentation of endogenous antigen	GO:0019883	6.37𝐸−04	0.1561
Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	GO:0002504	3.93𝐸−10	9.39𝐸−07
Chemokine activity	GO:0008009	3.80𝐸−06	0.0032
Chemokine receptor binding	GO:0042379	5.63𝐸−06	0.0041
Chemotaxis	GO:0006935	7.94𝐸−05	0.0362
Cytokine activity	GO:0005125	9.53𝐸−07	0.0010
Cytokine receptor binding	GO:0005126	1.44𝐸−04	0.0549
Defense response	GO:0006952/GO:0002217/GO:0042829	1.71𝐸−07	2.33𝐸−04
Extracellular region	GO:0005576	7.56𝐸−04	0.1764
Extracellular region part	GO:0044421	7.32𝐸−05	0.0362
Extracellular space	GO:0005615	4.03𝐸−06	0.0032
Fatty acid biosynthetic process	GO:0006633/GO:0000037	2.60𝐸−04	0.0890
G-protein-coupled receptor binding	GO:0001664	2.08𝐸−06	0.0020
Icosanoid biosynthetic process	GO:0046456	2.94𝐸−04	0.0971
Immune response	GO:0006955	1.69𝐸−13	8.08𝐸−10
Immune system process	GO:0002376	5.64𝐸−14	5.39𝐸−10
Inflammatory response	GO:0006954	2.28𝐸−05	0.0129
Locomotion	GO:0040011	6.67𝐸−04	0.1595
Membrane	GO:0016020	2.60𝐸−04	0.0890
Membrane raft	GO:0045121	1.34𝐸−04	0.0535
MHC class II protein complex	GO:0042613	8.24𝐸−11	2.63𝐸−07
MHC class II receptor activity	GO:0032395	3.53𝐸−07	4.22𝐸−04
MHC protein complex	GO:0042611	3.07𝐸−08	4.90𝐸−05
Multiorganism process	GO:0051704/GO:0051706	1.59𝐸−04	0.0583
Oligopeptide transport	GO:0006857	6.37𝐸−04	0.1561
Oligopeptide transporter activity	GO:0015198	6.37𝐸−04	0.1561
Phospholipid efflux	GO:0033700	8.16𝐸−04	0.1858
Polyamine biosynthetic process	GO:0006596	4.79𝐸−04	0.1273
Protein binding	GO:0005515/GO:0045308	3.67𝐸−04	0.1065
Receptor binding	GO:0005102	1.57𝐸−05	0.0094
Response to biotic stimulus	GO:0009607	5.09𝐸−05	0.0271
Response to other organisms	GO:0051707/GO:0009613/GO:0042828	5.97𝐸−06	0.0041
Response to stimulus	GO:0050896/GO:0051869	1.40𝐸−05	0.0089
Response to stress	GO:0006950	9.96𝐸−05	0.0414
Response to virus	GO:0009615	8.76𝐸−05	0.0381
Response to wounding	GO:0009611/GO:0002245	3.49𝐸−04	0.1065
Taxis	GO:0042330	7.94𝐸−05	0.0362
Unsaturated fatty acid biosynthetic process	GO:0006636	4.04𝐸−04	0.1138
Vacuolar membrane	GO:0005774	3.67𝐸−04	0.1065
Vacuolar part	GO:0044437	4.31𝐸−04	0.1179
Vacuole	GO:0005773	3.66𝐸−04	0.1065