Notch1 and 4 Signaling Responds to an Increasing Vascular Wall Shear Stress in a Rat Model of Arteriovenous Malformations
Figure 6
Blood flow shear stress increases interaction events between Notch receptor1 or 4 and their ligands in the “nidus” vessel wall with time over a period of 84 days after AVF formation. Time-course of interaction events between Notch receptor1 and its ligand Delta1 ((a); , ), Notch1 and Delta4 ((b); , ), Notch1 and Jagged1 ((c); , ), Notch receptor4 and Delta1 ((d); , ), Notch4 and Delta4 ((e); , ), and Notch4 and Jagged1 ((f); , ), respectively. Data were expressed as means ± SE of 4 rats at each time point. paired comparison between pre- (−1 day) and post-AVF formation at different time points.
