Notch1 and 4 Signaling Responds to an Increasing Vascular Wall Shear Stress in a Rat Model of Arteriovenous Malformations

<table>A positive correlation between WSS and the interaction events between Notch receptor1 or 4 and their ligands in the “nidus” vessel wall over a period of 84 days after AVF formation. A positive correlation between WSS and the interaction events between Notch1 and Delta1 (a), Notch1 and Delta4 (b), Notch1 and Jagged1 (c), Notch4 and Delta1 (d), Notch4 and Delta4 (e), and Notch4 and Jagged1 (f), respectively. Data were expressed as means ± SE of 4 rats at each time point. <svg height="13.95" id="M91" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> paired comparison between pre- (−1 day) and post-AVF formation at different time points.</table>

BioMed Research International

fig7

Figure 7

Figure 7: Notch1 and 4 Signaling Responds to an Increasing Vascular Wall Shear Stress in a Rat Model of Arteriovenous Malformations 