|NPY = (number of cigarettes smoked per day × number of years smoking)/20. |
**Comorbidity was defined as the presence of diabetes mellitus, hypertension, dyslipidemia, and/or cardiac disorders beyond rheumatoid arthritis.
Drugs coadministered with methotrexate when clinical response to methotrexate was recorded.
#Patients in compliance with folic acid supplementation.
ANAs: antinuclear antibodies; Anti-CCP: anti-cyclic citrullinated peptide; BMI: body mass index; DAS28: disease activity score 28; DMARDs: disease modifying antirheumatic drugs; ESR: erythrocyte sedimentation rate; HAQ: health assessment questionnaire; IQR: interquartile range; NPY: number of pack years; NSAIDs: nonsteroidal anti-inflammatory drugs; RF: rheumatoid factor; SD: standard deviation; SJC: swollen joints count; TJC: tender joints count; VAS: visual analog scale.