Gene Modification of Mesenchymal Stem Cells and Articular Chondrocytes to Enhance Chondrogenesis

Table 2

Candidate miRNAs to enhance chondrogenesis in MSCs and dedifferentiated chondrocytes.

MicroRNA	Cell type used	Result	Reference
miR-199a	C3H10T1/2 stem cells	Knockdown of Smad1	[71]
miR-675	Human articular chondrocytes	Enhancement of Collagen II synthesis	[72]
miR-145	C3H10T1/2 stem cells	Knockdown of Sox9	[74, 75]
miR-21	Rat articular chondrocytes	Enhancement of chondrocyte proliferation	[76]
miR-140	C3H10T1/2 stem cells	Knockdown of ADAMTS-5 and CXCL12	[77, 78]