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BioMed Research International
Volume 2014, Article ID 370621, 9 pages
http://dx.doi.org/10.1155/2014/370621
Clinical Study

Efficacy of Autologous Bone Marrow Concentrate for Knee Osteoarthritis with and without Adipose Graft

1Regenerative Sciences, The Centeno-Schultz Clinic, 403 Summit Boulevard, Suite 201, Broomfield, CO 80021, USA
2Forensic Research and Analysis, Oregon Health and Science University, 425 NW 10th Avenue, Suite 306, Portland, OR 97209, USA

Received 19 May 2014; Revised 14 July 2014; Accepted 28 July 2014; Published 7 September 2014

Academic Editor: Jozef Zustin

Copyright © 2014 Christopher Centeno et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. C. Lawrence, D. T. Felson, C. G. Helmick et al., “Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II,” Arthritis and Rheumatism, vol. 58, no. 1, pp. 26–35, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. A. M. Weinstein, B. N. Rome, W. M. Reichmann et al., “Estimating the burden of total knee replacement in the United States.,” The Journal of Bone and Joint Surgery, vol. 95, no. 5, pp. 385–392, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. J. N. Insall, “Historical Development, classification, and characteristics of knee prostheses,” in Surgery of the Knee, J. N. Insall, Ed., Churchill Livingstone, New York, NY, USA, 2nd edition, 1993. View at Google Scholar
  4. S. M. Javad Mortazavi, H. Kakli, O. Bican, M. Moussouttas, J. Parvizi, and R. H. Rothman, “Perioperative stroke after total joint arthroplasty: prevalence, predictors, and outcome,” Journal of Bone and Joint Surgery A, vol. 92, no. 11, pp. 2095–2101, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. M. J. Morris, R. G. Molli, K. R. Berend, and A. V. Lombardi, “Mortality and perioperative complications after unicompartmental knee arthroplasty,” Knee, vol. 20, no. 3, pp. 218–220, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Lalmohamed, P. Vestergaard, C. Cooper et al., “Timing of stroke in patients undergoing total hip replacement and matched controls: a nationwide cohort study,” Stroke, vol. 43, no. 12, pp. 3225–3229, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Lalmohamed, P. Vestergaard, C. Klop et al., “Timing of acute myocardial infarction in patients undergoing total hip or knee replacement: a nationwide cohort study,” Archives of Internal Medicine, vol. 172, no. 16, pp. 1229–1235, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. P. R. Pinto, T. McIntyre, R. Ferrero, V. Araújo-Soares, and A. Almeida, “Persistent pain after total knee or hip arthroplasty: differential study of prevalence, nature, and impact,” Journal of Pain Research, vol. 6, pp. 691–703, 2013. View at Google Scholar
  9. M. Benke and B. Shaffer, “Viscosupplementation treatment of arthritis pain,” Current Pain and Headache Reports, vol. 13, no. 6, pp. 440–446, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. A. J. Cianflocco, “Viscosupplementation in patients with osteoarthritis of the knee,” Postgraduate Medicine, vol. 125, no. 1, pp. 97–105, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Khoshbin, T. Leroux, D. Wasserstein et al., “The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis,” Arthroscopy, vol. 29, no. 12, pp. 2037–2048, 2013. View at Publisher · View at Google Scholar
  12. F. Say, D. Gürler, K. Yener, M. Bülbül, and M. Malkoc, “Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis,” Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca, vol. 80, no. 4, pp. 278–283, 2013. View at Google Scholar
  13. E. Kon, G. Filardo, A. Di Martino, and M. Marcacci, “Platelet-rich plasma (PRP) to treat sports injuries: evidence to support its use,” Knee Surgery, Sports Traumatology, Arthroscopy, vol. 19, no. 4, pp. 516–527, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. M. F. Pittenger, A. M. Mackay, S. C. Beck et al., “Multilineage potential of adult human mesenchymal stem cells,” Science, vol. 284, no. 5411, pp. 143–147, 1999. View at Google Scholar
  15. C. Lange, J. Schroeder, M. V. Lioznov, and A. R. Zander, “High-potential human mesenchymal stem cells,” Stem Cells and Development, vol. 14, no. 1, pp. 70–80, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. “Autologous mesenchymal stem cells for treating knee osteoarthritis,” Managed Care, vol. 22, no. 8, pp. 15–16, 2013.
  17. C. J. Centeno, D. Busse, J. Kisiday, C. Keohan, M. Freeman, and D. Karli, “Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells,” Pain Physician, vol. 11, no. 3, pp. 343–353, 2008. View at Google Scholar · View at Scopus
  18. C. J. Centeno, “Clinical challenges and opportunities of mesenchymal stem cells in musculoskeletal medicine,” PM&R, vol. 6, no. 1, pp. 70–77, 2014. View at Publisher · View at Google Scholar
  19. Y. Qi, G. Feng, and W. Yan, “Mesenchymal stem cell-based treatment for cartilage defects in osteoarthritis,” Molecular Biology Reports, vol. 39, no. 5, pp. 5683–5689, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. J. I. Huang, P. A. Zuk, N. F. Jones et al., “Chondrogenic potential of multipotential cells from human adipose tissue,” Plastic and Reconstructive Surgery, vol. 113, no. 2, pp. 585–594, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Pak, “Autologous adipose tissue-derived stem cells induce persistent bone-like tissue in osteonecrotic femoral heads,” Pain Physician, vol. 15, no. 1, pp. 75–85, 2012. View at Google Scholar · View at Scopus
  22. L. Casteilla, V. Planat-Benard, P. Laharrague, and B. Cousin, “Adipose-derived stromal cells: their identity and uses in clinical trials, an update,” World Journal of Stem Cells, vol. 3, no. 4, pp. 25–33, 2011. View at Google Scholar
  23. G. Desando, C. Cavallo, F. Sartoni et al., “Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model,” Arthritis Research and Therapy, vol. 15, no. 1, article R22, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. C. J. Centeno, D. Busse, J. Kisiday, C. Keohan, M. Freeman, and D. Karli, “Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells,” Medical Hypotheses, vol. 71, no. 6, pp. 900–908, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. C. J. Centeno, J. R. Schultz, M. Cheever et al., “Safety and complications reporting update on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique,” Current Stem Cell Research and Therapy, vol. 6, no. 4, pp. 368–378, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. C. J. Centeno, J. R. Schultz, M. Cheever, B. Robinson, M. Freeman, and W. Marasco, “Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique,” Current Stem Cell Research and Therapy, vol. 5, no. 1, pp. 81–93, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. C. J. Centeno, J. R. Schultz, M. Cheever, M. Freeman, B. Robinson, and S. Faulkner, “A Case Series of Percutaneeous Treatment of Non-Union Fractures with Autologous, Culture Expanded, Bone Marrow Dervied, Mesenchymal Stem Cells and Platelet Lysate,” Bioengineering & Biomedical Science, 2011.
  28. C. J. Centeno and M. D. Freeman, “Percutaneous injection of autologous, culture-expanded mesenchymal stem cells into carpometacarpal hand joints: a case series with an untreated comparison group,” Wiener Medizinische Wochenschrift, vol. 164, no. 5-6, pp. 83–87, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. U.S. Department of Health and Human Services, Ed., Guidance for Clinical Investigators, Sponsors, and IRBs Adverse Event Reporting to IRBs—Improving Human Subject Protection, Office of the Commissioner, the Center for Drug Evaluation and Research (CDER), the Center for Biologics Evaluation and Research (CBER), the Center for Devices and Radiological health (CDRH), and the Good CLinical Practice Program (GCPP) at the Food and Drug Administration, 2009.
  30. J. H. Kellgren and J. S. Lawrence, “Radiological assessment of osteo-arthrosis,” Annals of the Rheumatic Diseases, vol. 16, no. 4, pp. 494–502, 1957. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Sowers, C. A. Karvonen-Gutierrez, J. A. Jacobson, Y. Jiang, and M. Yosef, “Associations of anatomical measures from MRI with radiographically defined knee osteoarthritis score, pain, and physical functioning,” Journal of Bone and Joint Surgery A, vol. 93, no. 3, pp. 241–251, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. S. C. Bagley, H. White, and B. A. Golomb, “Logistic regression in the medical literature: standards for use and reporting, with particular attention to one medical domain,” Journal of Clinical Epidemiology, vol. 54, no. 10, pp. 979–985, 2001. View at Publisher · View at Google Scholar · View at Scopus
  33. F. I. Lewis and M. P. Ward, “Improving epidemiologic data analyses through multivariate regression modelling,” Emerging Themes in Epidemiology, vol. 10, no. 1, article 4, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. J. M. Binkley, P. W. Stratford, S. A. Lott, and D. L. Riddle, “The Lower Extremity Functional Scale (LEFS): scale development, measurement properties, and clinical application,” Physical Therapy, vol. 79, no. 4, pp. 371–383, 1999. View at Google Scholar · View at Scopus
  35. A. M. Kelly, “The minimum clinically significant difference in visual analogue scale pain score does not differ with severity of pain,” Emergency Medicine Journal, vol. 18, no. 3, pp. 205–207, 2001. View at Publisher · View at Google Scholar · View at Scopus
  36. SAS 9.4 Software, SAS Institute Inc, Cary, NC, USA, 2014.
  37. M. R. Chen and J. L. Dragoo, “The effect of nonsteroidal anti-inflammatory drugs on tissue healing,” Knee Surgery, Sports Traumatology, Arthroscopy, vol. 21, no. 3, pp. 540–549, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. M. E. Wiggins, P. D. Fadale, H. Barrach, M. G. Ehrlich, and W. R. Walsh, “Healing characteristics of a type I collagenous structure treated with corticosteroids,” The American Journal of Sports Medicine, vol. 22, no. 2, pp. 279–288, 1994. View at Publisher · View at Google Scholar · View at Scopus
  39. W. Tsai, C. Hsu, C. P. C. Chen, M. J. L. Chen, M. Lin, and J. S. Pang, “Ibuprofen inhibition of tendon cell migration and down-regulation of paxillin expression,” Journal of Orthopaedic Research, vol. 24, no. 3, pp. 551–558, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. W.-C. Tsai, F.-T. Tang, M.-K. Wong, and J.-H. S. Pang, “Inhibition of tendon cell migration by dexamethasone is correlated with reduced alpha-smooth muscle actin gene expression: a potential mechanism of delayed tendon healing,” Journal of Orthopaedic Research, vol. 21, no. 2, pp. 265–271, 2003. View at Publisher · View at Google Scholar · View at Scopus
  41. P. Randelli, F. Randelli, P. Cabitza, and L. Vaienti, “The effects of COX-2 anti-inflammatory drugs on soft tissue healing: a review of the literature,” Journal of Biological Regulators and Homeostatic Agents, vol. 24, no. 2, pp. 107–114, 2010. View at Google Scholar · View at Scopus
  42. D. Goyal, S. Keyhani, E. H. Lee, and J. H. Hui, “Evidence-based status of microfracture technique: a systematic review of level I and II studies,” Arthroscopy, vol. 29, no. 9, pp. 1579–1588, 2013. View at Publisher · View at Google Scholar
  43. B. Moradi, E. Schönit, C. Nierhoff et al., “First-generation autologous chondrocyte implantation in patients with cartilage defects of the knee: 7 to 14 years' clinical and magnetic resonance imaging follow-up evaluation,” Arthroscopy, vol. 28, no. 12, pp. 1851–1861, 2012. View at Publisher · View at Google Scholar · View at Scopus
  44. O. A. Behery, J. D. Harris, J. M. Karnes, R. A. Siston, and D. C. Flanigan, “Factors influencing the outcome of autologous chondrocyte implantation: a systematic review,” Journal of Knee Surgery, vol. 26, no. 3, pp. 203–211, 2013. View at Google Scholar
  45. T. R. Liebs, W. Herzberg, A. M. Roth-Kroeger, W. Rüther, and J. Hassenpflug, “Women recover faster than men after standard knee arthroplasty,” Clinical Orthopaedics and Related Research, vol. 469, no. 10, pp. 2855–2865, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. S. J. MacDonald, K. D. Charron, R. B. Bourne, D. D. Naudie, R. W. McCalden, and C. H. Rorabeck, “The John Insall award: gender-specific total knee replacement: prospectively collected clinical outcomes,” Clinical Orthopaedics and Related Research, vol. 466, no. 11, pp. 2612–2616, 2008. View at Publisher · View at Google Scholar · View at Scopus
  47. P. L. Santaguida, G. A. Hawker, P. L. Hudak et al., “Patient characteristics affecting the prognosis of total hip and knee joint arthroplasty: a systematic review,” Canadian Journal of Surgery, vol. 51, no. 6, pp. 428–436, 2008. View at Google Scholar · View at Scopus
  48. M. J. McElroy, R. Pivec, K. Issa, S. F. Harwin, and M. A. Mont, “The effects of obesity and morbid obesity on outcomes in TKA,” The Journal of Knee Surgery, vol. 26, no. 2, pp. 83–88, 2013. View at Publisher · View at Google Scholar · View at Scopus
  49. A. J. Samson, G. E. Mercer, and D. G. Campbell, “Total knee replacement in the morbidly obese: a literature review,” ANZ Journal of Surgery, vol. 80, no. 9, pp. 595–599, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. M. S. Sridhar, C. D. Jarrett, J. W. Xerogeanes, and S. A. Labib, “Obesity and symptomatic osteoarthritis of the knee,” Journal of Bone and Joint Surgery B, vol. 94, no. 4, pp. 433–440, 2012. View at Publisher · View at Google Scholar · View at Scopus
  51. G. N. Gillespie and A. J. Porteous, “Obesity and knee arthroplasty,” Knee, vol. 14, no. 2, pp. 81–86, 2007. View at Publisher · View at Google Scholar · View at Scopus
  52. A. K. Amin, J. T. Patton, R. E. Cook, and I. J. Brenkel, “Does obesity influence the clinical outcome at five years following total knee replacement for osteoarthritis?” Journal of Bone and Joint Surgery B, vol. 88, no. 3, pp. 335–340, 2006. View at Publisher · View at Google Scholar · View at Scopus
  53. G. A. Tynan, C. H. Hearnden, E. Oleszycka et al., “Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation,” Diabetes, vol. 63, no. 6, pp. 2037–2050, 2014. View at Publisher · View at Google Scholar
  54. P. J. Belmont Jr., G. P. Goodman, B. R. Waterman, J. O. Bader, and A. J. Schoenfeld, “Thirty-day postoperative complications and mortality following total knee arthroplasty: incidence and risk factors among a national sample of 15,321 patients,” Journal of Bone and Joint Surgery A, vol. 96, no. 1, pp. 20–26, 2014. View at Publisher · View at Google Scholar
  55. R. A. Ward and M. E. Brier, “Retrospective analyses of large medical databases: what do they tell us?” Journal of the American Society of Nephrology, vol. 10, no. 2, pp. 429–432, 1999. View at Google Scholar · View at Scopus