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BioMed Research International
Volume 2014, Article ID 371809, 7 pages
Review Article

In Silico Modeling of the Immune System: Cellular and Molecular Scale Approaches

1Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy
2Department of Mathematics and Computer Science, University of Catania, V.le A. Doria 6, 95125 Catania, Italy

Received 27 February 2014; Accepted 5 March 2014; Published 6 April 2014

Academic Editor: Filippo Castiglione

Copyright © 2014 Mariagrazia Belfiore et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The revolutions in biotechnology and information technology have produced clinical data, which complement biological data. These data enable detailed descriptions of various healthy and diseased states and responses to therapies. For the investigation of the physiology and pathology of the immune responses, computer and mathematical models have been used in the last decades, enabling the representation of biological processes. In this modeling effort, a major issue is represented by the communication between models that work at cellular and molecular level, that is, multiscale representation. Here we sketch some attempts to model immune system dynamics at both levels.