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BioMed Research International
Volume 2014 (2014), Article ID 375423, 12 pages
http://dx.doi.org/10.1155/2014/375423
Review Article

Indole Alkaloids from Marine Sources as Potential Leads against Infectious Diseases

1Institute of Chemistry and Biotechnology, Federal University of Alagoas, University City, BR 101, KM 14 Norte, Tabuleiro dos Martins, 57072-970 Maceio, AL, Brazil
2School of Nursing and Pharmacy, Federal University of Alagoas, Av. Lourival de Mello Motta, S/N, Tabuleiro dos Martins, 57072-970 Maceió, AL, Brazil
3Laboratory of Pharmaceutical Technology, Federal University of Paraiba, 58051-900 João Pessoa, PB, Brazil
4Department of Physiology, Federal University of Sergipe, 49000-100 São Cristóvão, SE, Brazil

Received 23 February 2014; Revised 25 April 2014; Accepted 25 April 2014; Published 5 June 2014

Academic Editor: Xudong Huang

Copyright © 2014 Paulo H. B. França et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious diseases is based on a small number of chemotherapeutic agents. Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents. In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.