Review Article
Emerging Rapid Resistance Testing Methods for Clinical Microbiology Laboratories and Their Potential Impact on Patient Management
Table 5
Approximate turn-around-time, investment costs, reagent costs, and necessity of skilled personnel of different rapid diagnostic test procedures.
| Rapid diagnostic procedure | Turn-around-time | Investment costs | Reagents costs (per sample) | Necessity of skilled personnel |
| Agglutination assays | <5 minutes | — | <1.00€ | Low | Fluorescence in situ hybridization | 1-2 hours | <15,000.00€ | 1.00–8.00€ | Intermediate | Real-time PCR (including DNA preparation) | 4–6 hours | 35,000.00–60,000.00€ | 15.00–25.00€ | Strongly depending on the test system | Loop-mediated isothermal amplification (LAMP) assays | <1 hour | 2,000.00–4,000.00€ | 15.00–25.00€ | Intermediate | Next generation sequencing (NGS) | 2–5 days | 350,000.00–750,000.00€ | 75.00–800.00€ | Very high | Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) | <5 minutes | 75,000.00–300,000.00€ | <1.00€ | High |
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