Follistatin, an Activin Antagonist, Ameliorates Renal Interstitial Fibrosis in a Rat Model of Unilateral Ureteral Obstruction

<table>Effects of follistatin on fibrotic changes in kidneys after UUO. (a) Histological changes in kidneys after UUO were assessed by PAS staining. (A, D) contralateral kidneys, 7 days. (B, E) saline-treated UUO kidneys, 7 days. (C, F) follistatin-treated UUO kidneys, 7 days. Magnification: ×100 (A–C), ×400. (b) Fibrotic changes in kidneys after UUO were assessed by Masson-trichrome staining. (A, C) saline-treated UUO kidneys, 7 days. (B, D) follistatin-treated UUO kidneys, 7 days. Magnification: ×100 (A, B), ×400 (C, D). (c) Semiquantitative analysis of fibrotic changes in UUO kidneys. Fibrotic score was measured as described in Section <a href="https://static.hindawi.com/articles/bmri/volume-2014/376191/figures/#sec2">2</a>. Data are presented as mean ± SE (<svg height="10.925" id="M9" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 36.237499 10.925" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus saline.</table>

BioMed Research International

fig2

Figure 2

Figure 2: Follistatin, an Activin Antagonist, Ameliorates Renal Interstitial Fibrosis in a Rat Model of Unilateral Ureteral Obstruction 