Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 379340, 11 pages
Research Article

Lentiviral Protein Transduction with Genome-Modifying HIV-1 Integrase-I-PpoI Fusion Proteins: Studies on Specificity and Cytotoxicity

1Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70210 Kuopio, Finland
2FinVector Vision Therapies Oy, 70210 Kuopio, Finland
3FKD Therapies Oy, 70210 Kuopio, Finland
4Department of Medicine, University of Eastern Finland, 70120 Kuopio, Finland
5Gene Therapy Unit, Kuopio University Hospital, 70120 Kuopio, Finland

Received 26 January 2014; Accepted 12 March 2014; Published 22 April 2014

Academic Editor: Brian Oliver

Copyright © 2014 Vesa Turkki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The supplementary material includes following data: The correct vector-incorporation of IN-I-PpoIH78A and its endonuclease activity, verification of non-cytotoxic LVV dose for MRC-5 cells, viabilities of cells treated with varying amounts of LVV-IN-I-PpoI and comparison of the end-viabilities between cancerous and non-cancerous cells.

  1. Supplementary Figures