Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 380124, 10 pages
Review Article

Radiosynthesis of [18F]Trifluoroalkyl Groups: Scope and Limitations

1Kjemisk Institutt, Universitetet I Oslo, Sem Sælands Vei 26, 0376 Oslo, Norway
2Norsk Medisinsk Syklotronsenter AS, Postboks 4950 Nydalen, 0424 Oslo, Norway

Received 20 March 2014; Revised 21 April 2014; Accepted 6 May 2014; Published 10 July 2014

Academic Editor: Olaf Prante

Copyright © 2014 V. T. Lien and P. J. Riss. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present paper is concerned with radiochemical methodology to furnish the trifluoromethyl motif labelled with 18F. Literature spanning the last four decades is comprehensively reviewed and radiochemical yields and specific activities are discussed.