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BioMed Research International
Volume 2014, Article ID 381917, 6 pages
http://dx.doi.org/10.1155/2014/381917
Review Article

MicroRNA Era: The Importance for Diagnosis and Prognosis of Adrenocortical Tumors

1Instituto do Câncer do Estado de São Paulo (ICESP), 05403-000 Sao Paulo, SP, Brazil
2Laboratório de Hormônios e Genética Molecular LIM/42 do Hospital das Clínicas, Disciplina de Endocrinologia e Metabologia da Faculdade de Medicina da Universidade de São Paulo, 05403-000 Sao Paulo, SP, Brazil

Received 27 March 2014; Accepted 27 May 2014; Published 23 June 2014

Academic Editor: Maricilda Palandi de Mello

Copyright © 2014 João Evangelista Bezerra and Ana Claudia Latronico. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

MicroRNAs play an essential role in posttranscriptional regulation of gene expression. They are evolutionary conserved, small, noncoding, 19–22-nucleotide RNAs, whose abnormalities, such as up- or downregulated expression, have been associated with several neoplasms, including adrenocortical tumors. Expression levels of distinct microRNAs can distinguish benign from malignant adrenal tumors. This current review provides recent data on the miRNAs profile in benign and malignant adrenocortical tumors diagnosed in adult and pediatric patients.