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Figure 4: Neutralization of TNF- ameliorates LPS-induced cardiac damage in APN-KO mice.Quantitative analysis of %FS following treatment with etanercept, a soluble TNF receptor or vehicle, in APN-KO mice 6 h after LPS injection (). Etanercept (8 mg/kg) or vehicle was given by intraperitoneal injection in APN-KO mice 1 d before LPS treatment. Results are presented as mean ± SE.