Antileishmanial, Toxicity, and Phytochemical Evaluation of Medicinal Plants Collected from Pakistan

Table 2

Antileishmanial and toxicity activity of J. dolomiaea, A. gracilis, S. cordata, and S. media methanol extract and its derived fractions.

Sample	Antileishmanial		Toxicity
	𝑅^2	IC50 (𝜇g/mL)	𝑅^2	LC50 (𝜇g/mL)
J. dolomiaea
JDME	0.84	10.9 ± 1.1	1.00	733.0 ± 15.1
JDHE	0.95	7.2 ± 0.5	0.98	982.5 ± 12.3
JDCE	0.81	47.7 ± 2.3	0.98	834.5 ± 8.5
JDEE	0.98	5.3 ± 0.2	0.98	569.5 ± 7.4
JDBE	0.97	21.8 ± 2.4	0.95	958.3 ± 10.8
JDAE	0.97	6.0 ± 0.1	0.92	1593 ± 20.2
A. gracilis
AGME	0.82	33.9 ± 1.5	0.71	321.5 ± 11.5
AGHE	0.79	36.6 ± 1.4	0.97	280.6 ± 4.3
AGCE	0.94	28.3 ± 3.5	0.86	383.5 ± 9.5
AGEE	0.92	13.5 ± 0.7	0.94	211.9 ± 3.7
AGBE	0.95	18.9 ± 1.2	0.84	588.6 ± 7.2
AGAE	0.98	12.6 ± 1.5	0.89	460 ± 12.5
S. cordata
SCME	0.90	41.8 ± 2.1	0.99	125.7 ± 1.5
SCHE	0.90	9.2 ± 0.7	0.75	879.5 ± 1.3
SCCE	0.89	125.5 ± 4.5	0.84	802.8 ± 4.7
SCEE	0.74	56.8 ± 5.5	0.94	309.9 ± 3.3
SCBE	0.98	228.5 ± 10.2	0.92	882.4 ± 6.3
SCAE	0.92	259.1 ± 12.5	0.94	211.9 ± 2.9
S. media
SMME	0.95	185.9 ± 7.5	0.99	436.7 ± 8.2
SMHE	0.99	170.4 ± 5.5	0.88	542.5 ± 10.4
SMCE	0.83	155.5 ± 3.8	0.98	600.0 ± 6.5
SMEE	0.85	36.4 ± 2.5	0.85	789.3 ± 2.7
SMBE	0.93	49.5 ± 3.5	0.95	760.2 ± 13.6
SMAE	0.98	184.8 ± 5.8	0.96	660.7 ± 2.5
Glucantime	0.99	5.6 ± 0.25	—	—
Tricaine methanesulfonate	—	—	0.93	4.3 ± 0.15

—: represents activity not performed.