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BioMed Research International
Volume 2014, Article ID 386473, 9 pages
http://dx.doi.org/10.1155/2014/386473
Research Article

Anticancer, Anti-Inflammatory, and Analgesic Activities of Synthesized 2-(Substituted phenoxy) Acetamide Derivatives

1Department of Chemistry, School of Sciences, IFTM University, Moradabad, Uttar Pradesh, India
2Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Koni, Bilaspur, Chhattisgarh 495 009, India
3Department of Pharmaceutics, School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh, India
4Department of Chemistry, School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh, India

Received 27 February 2014; Revised 22 July 2014; Accepted 29 July 2014; Published 14 August 2014

Academic Editor: Raymond L. Konger

Copyright © 2014 Priyanka Rani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. I. Johnsen, M. Lindskog, F. Ponthan et al., “Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo,” Cancer Research, vol. 64, no. 20, pp. 7210–7215, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Sonoshita, K. Takaku, M. Oshima, K. Sugihara, and M. M. Taketo, “Cyclooxygenase-2 expression in fibroblasts and endothelial cells of intestinal polyps,” Cancer Research, vol. 62, no. 23, pp. 6846–6849, 2002. View at Google Scholar · View at Scopus
  3. K. M. Sheehan, “The relationship between cyclooxygenase-2 expression and colorectal cancer,” Journal of American Medical Association, vol. 282, pp. 1254–1257, 1999. View at Google Scholar
  4. M. Philip, D. A. Rowley, and H. Schreiber, “Inflammation as a tumor promoter in cancer induction,” Seminars in Cancer Biology, vol. 14, no. 6, pp. 433–439, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. A. S. Kalgutkar and Z. Zhao, “Discovery and design of selective cyclooxygenase-2 inhibitors as non-ulcerogenic, anti-inflammatory drugs with potential utility as anti-cancer agents,” Current Drug Targets, vol. 2, no. 1, pp. 79–106, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. G. M. Pasinetti, “Cyclooxygenase and Inflammation in Alzheimers disease: experimental approaches and clinical interventions,” Journal of Neuroscience Research, vol. 54, no. 1, pp. 1–6, 1998. View at Google Scholar
  7. L. M. Coussens and Z. Werb, “Inflammation and cancer,” Nature, vol. 420, no. 6917, pp. 860–867, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. M. P. Schrey and K. V. Patel, “Prostaglandin E2 production and metabolism in human breast cancer cells and breast fibroblasts. Regulation by inflammatory mediators,” British Journal of Cancer, vol. 72, no. 6, pp. 1412–1419, 1995. View at Publisher · View at Google Scholar · View at Scopus
  9. D. T. Hill and B. Loev, “4-(2-Thienyl)-5-methylpyrimidine. An anomalous Leuckart product,” Journal of Organic Chemistry, vol. 38, no. 11, pp. 2102–2103, 1973. View at Publisher · View at Google Scholar · View at Scopus
  10. R. D. Bach, “Preparation of tertiary N,N-dimethylamines by the leuckart reaction,” The Journal of Organic Chemistry, vol. 33, no. 4, pp. 1647–1649, 1968. View at Publisher · View at Google Scholar · View at Scopus
  11. L. H. Sternbach, “The benzodiazepine story,” Journal of Medicinal Chemistry, vol. 22, no. 1, pp. 1–7, 1979. View at Publisher · View at Google Scholar · View at Scopus
  12. D. E. Thurston and D. S. Bose, “Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines,” Chemical Reviews, vol. 94, no. 2, pp. 433–465, 1994. View at Publisher · View at Google Scholar · View at Scopus
  13. M. B. Gupta, R. Nath, G. P. Gupta, and K. P. Bhargava, “A study of the anti-ulcer activity of diazepam and other tranquillosedatives in albino rats,” Clinical and Experimental Pharmacology and Physiology, vol. 12, no. 1, pp. 61–66, 1985. View at Publisher · View at Google Scholar · View at Scopus
  14. J. R. Lokensgard, C. C. Chao, G. Gekker, S. Hu, and P. K. Peterson, “Benzodiazepines, glia, and HIV-1 neuropathogenesis,” Molecular Neurobiology, vol. 18, no. 1, pp. 23–33, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Z. Ding, R. Batorsky, R. Bhide et al., “Discovery and structure-activity relationships of imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase,” Journal of Medicinal Chemistry, vol. 42, no. 25, pp. 5241–5253, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. W. Ang, Y. Lin, T. Yang et al., “Synthesis and biological evaluation of 2-(3-Fluoro-4-nitro phenoxy)-N-phenylacetamide derivatives as novel potential affordable antitubercular agents,” Molecules, vol. 17, no. 2, pp. 2248–2258, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. L. K. Hedstrom and B. Striepen, “IMP dehydrogenase inhibitors for treating mammalian gastrointestinal parasitic infections,” WO 2007143557, 2007. View at Google Scholar
  18. A. Sun, A. Prussia, W. Q. Zhan et al., “Nonpeptide inhibitors of measles virus entry,” Journal of Medicinal Chemistry, vol. 49, no. 17, pp. 5080–5092, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. S. K. Tipparaju, S. P. Muench, E. J. Mui et al., “Identification and development of novel inhibitors of toxoplasma gondii enoyl reductase,” The Journal of Medicinal Chemistry, vol. 53, no. 17, pp. 6287–6300, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Lee, S. H. Roh, Y. Xia, and K. W. Kang, “Synthesis and biological evaluation of phenoxy-N-phenylacetamide derivatives as novel P-glycoprotein inhibitors,” Bulletin of the Korean Chemical Society, vol. 32, no. 10, pp. 3666–3674, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. D. Pal, S. Banerjee, and A. K. Ghosh, “Dietary-induced cancer prevention: An expanding research arena of emerging diet related to healthcare system,” Journal of Advanced Pharmaceutical Technology and Research, vol. 3, no. 1, pp. 16–24, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Pal and S. Mitra, “A preliminary study on the in vitro antioxidant activity of the stems of Opuntia vulgaris,” Journal of Advanced Pharmaceutical Technology and Research, vol. 1, no. 2, pp. 268–272, 2010. View at Google Scholar · View at Scopus
  23. A. K. Nayak, D. Pal, D. R. Pany, and B. Mohanty, “Evaluation of Spinacia oleracea L. leaves mucilage as an innovative suspending agent,” Journal of Advanced Pharmaceutical Technology and Research, vol. 1, no. 3, pp. 338–341, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. OCED/OCDC and OECD, “Guidelines for testing of chemicals. Revised draft guidelines 423, acute oral toxicity class method, Revised document,” 2000.
  25. C. A. Winter, E. A. Risley, and G. W. Nuss, “Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs,” Proceedings of the Society for Experimental Biology and Medicine, vol. 3, pp. 544–547, 1962. View at Publisher · View at Google Scholar · View at Scopus
  26. B. B. Newbould, “Chemotherapy of arthritis induced in rats by mycobacterial adjuvant,” British Journal of Pharmacology and Chemotherapy, vol. 21, pp. 127–136, 1963. View at Publisher · View at Google Scholar · View at Scopus
  27. N. B. Eddy and D. J. Leimbach, “Synthetic analgesics II. Dithienylbutenyl and dithienylbutylamines,” Journal of Pharmacology and Experimental Therapeutics, vol. 107, no. 3, pp. 385–393, 1953. View at Google Scholar
  28. V. Mathew, J. Keshavayya, V. P. Vaidya, and D. Giles, “Studies on synthesis and pharmacological activities of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and their dihydro analogues,” European Journal of Medicinal Chemistry, vol. 42, no. 6, pp. 823–840, 2007. View at Publisher · View at Google Scholar · View at Scopus