Anticancer, Anti-Inflammatory, and Analgesic Activities of Synthesized 2-(Substituted phenoxy) Acetamide Derivatives

Table 1

Characterization data of N-(1-(4-chlorophenyl)ethyl)-2-(Substituted phenoxy)acetamide derivatives (3a–e) and 2-(substituted phenoxy)-N-(1-(p-tolyl)ethyl)acetamide derivatives (3f–j).

Compound	R	Yield (%)	Melting point* (°C)	Rf value^#	Molecular formula
3a	H	61.4	171–173	0.37	C16H16ClNO2
3b	4-Br	58.3	154–156	0.45	C16H15BrClNO2
3c	4-NO2	59.1	165–167	0.41	C16H15ClN2O4
3d	4-C-(CH3)3	62.7	205–207	0.50	C20H24ClNO2
3e	4-OCH3	71.0	126–128	0.38	C17H18ClNO3
3f	H	67.8	154–156	0.32	C17H19NO2
3g	4-Br	57.2	189–191	0.46	C17H18BrNO2
3h	4-NO2	74.5	148–150	0.51	C17H18N2O4
3i	4-C-(CH3)3	65.9	172–174	0.39	C21H27NO2
3j	4-OCH3	70.4	142–144	0.47	C18H21NO3

*Recrystallization with ethanol. ^#Stationary phase: silica gel; mobile phase: n-hexane : ethyl acetate (1 : 1); iodine vapors as visualizing agent.