The Study of Interactions between Active Compounds of Coffee and Willow (Salix sp.) Bark Water Extract

Table 3

Comparison of interaction factors (IF) of mixtures of coffee with willow bark preparation.

Sample	Willow bark	Activity	𝐴𝑀^∗	𝐴𝑇^∗∗	IF***
Coffee/willow bark preparation mixture (1 : 1 [w/w])	S. myrsinifolia	Antiradical potential	9.97	6.66	1.50
		Reducing power	1.49	2.28	0.65
		Inhibition of lipid peroxidation	1.27	7.55	0.17
	S. purpurea	Antiradical potential	5.67	8.84	1.48
		Reducing power	1.79	3.35	0.54
		Inhibition of lipid peroxidation	1.40	7.67	0.18

∗Measured activity (𝐴_𝑀) of a mixture of samples (expressed as EC₅₀ [mg/mL]).
∗∗Theoretically calculated mixture activity (𝐴_𝑇) (based on the dose response of single components at various concentrations) (expressed as EC₅₀ [mg/mL]).
∗∗∗Interaction factor (IF) value < 1 indicates synergistic interaction; IF > 1 indicates antagonism; IF ≈ 1 indicates additional interactions.