Progress and Prospects in Human Genetic Research into Age-Related Hearing Impairment

Table 1

Recent reports regarding association between ARHI and monogenic forms of hearing impairment.

Genes causing monogenic hearing impairment with phenotypic similarities to ARHI
Genes	Monogenic nonsyndromic hearing impairment	Authors	Reference	Publication year	Object region or ancestry of the study subjects	Remarks
GRHL2/TFCP2L3/BOM (OMIM: 608576)	DFNA28	van Laer et al.	[3]	2008	9 centers in 7 European countries	Authors have concluded that GRHL2 is an ARHI susceptibility gene.
		Lin et al.	[4]	2011	Taiwan	No positive association was found.
KCNQ4 (OMIM: 603537)	DFNA2	van Eyken et al.	[5]	2006	Netherlands and Belgium	Several SNPs in this gene were significantly associated with ARHI.
DFNA5 (OMIM: 608798)	DFNA5	van Laer et al.	[6]	2002	Framingham in USA	Authors have concluded that no strong association exists between DFNA5 and ARHI.
COCH (OMIM: 603196)	DFNA9	Fransen et al.	[7]	2004	Belgium and Netherlands	No significant effect of the SNP for ARHI was found.
GIPC3 (OMIM: 608792)	DFNB15/DFNB72/DFNB95	Charizopoulou et al.	[8]	2011	Families of Dutch and Indian origin	A missense mutation of Gipc3 was associated with age-related hearing loss 5 (ahl5) in mice and point mutations of human GIPC3 were found in hearing loss cases segregating in two small human families.
		Rehman et al.	[9]	2011	Pakistani families	Authors reported seven mutations of GIPC3 associated with mild to profound hearing loss segregating in seven large families.
MYO6 (OMIM: 600970)	DFNA22/DFNB37	Oonk et al.	[10]	2013	Dutch family	The audiological findings in the Dutch DFNA22 family supported the hypothesis that the phenotype of the specific MYO6 mutation mimics presbycusis.