Outcome and Prognostic Factors in T4a Oropharyngeal Carcinoma, Including the Role of HPV Infection

Table 1

Oncologic results according to treatment group.

Treatment group	Number of patients	5-Y-KM-Estimate (%) (total number of events) (95% CI)
		OS	DSS	LC	RC	DC
Primary surgical group	83	41.2 (67) (30–52)	52.7 (35) (41–65)	74.2 (16) (63–86)	* 84.7 (8) (75–95)	* 86.5 (6) (76–97)
Surgery	19	30.4 (16) (6–54)	*47.2 (8) (19–75)	*55.6 (5) (26–85)	*67.5 (2) (27–100)	No events*
Surgery + RT	38	38.9 (33) (21–52)	41.8 (20) (25–58)	*75.7 (8) (6–91)	*81.6 (5) (67–96)	*90.0 (2) (76–100)
Surgery + RCT	26	56.7 (18) (37–76)	*72.7 (7) (54–92)	*87.5 (3) (71–100)	*95.8 (1) (87–100)	56.7 (18) (37–76)
Primary conservative group	316	17.3 (263) (13–22)	31.4 (184) (23–39)	83.8 (43) (79–89)	91.8 (11) (86–97)	80.4 (20) (71–89)
RCT ± salvage	151	18.6 (129) (12–25)	33.8 (91) (24–42)	83.5 (21) (76–91)	*96.0 (4) (92–100)	76.8 (11) (62–91)
RT ± salvage	165	16.8 (134) (11–23)	29.6 (93) (21–38)	84.2 (22) (78–91)	*88.8 (7) (80–98)	83.0 (9) (71–95)

∗Not enough events or patients for statistical analysis.