Research Article
Outcome and Prognostic Factors in T4a Oropharyngeal Carcinoma, Including the Role of HPV Infection
Table 4
Univariate analysis of potential prognostic factors for DSS, OS, LC, RC and distant metastases.
| | Variable (number of patients) |
KM estimates, total number of events, and 95% CI concerning defined events
5-Y-KM-Estimate % (total number of events) (95% CI) | | Local control (LC) | Neck control (NC) | Distant metastases | Disease-specific survival (DSS) | Overall survival (OS) |
| | Age (years) | | | | | | | ≤54 (223) | 77.0 (39) (70–84) | 90.1 (10) (83–97) | 81.6 (18) (73–90) | 31.3 (134) (24–38) | 20.8 (190) (15–26) | | >54 (203) | 85.3 (26) (80–91) | 87.6 (12) (80–95) | 86.1 (9) (77–95) | 41.0 (100) (33–49) | 22.5 (164) (16–29) | | | | | | | | | Gender | | | | | | | Male (374) | 80.4 (59) (75–85) | 87.6 (21) (82–93) | 82.7 (23) (75–90) | 34.0 (212) (28–40) | 19.9 (313) (16–24) | | Female (52) |
*87.0 (6) (77–97) |
*89.1 (1) (84–94) |
*86.6 (4) (74–99) | 47.5 (100) (42–73) | 32.8 (41) (20–46) | | |
+ |
+ |
+ |
+ |
+ | | Tumor subsite | | | | | | | Tonsillar region (173) | 82.8 (26) (76–89) | 83.5 (10) (73–94) | 80.4 (14) (70–91) | 32.0 (99) (24–40) | 19.3 (147) (13–25) | | Soft palate (25) |
*72.2 (5) (49–95) |
*95.0 (1) (85–100) |
*635 (3) (25–100) | 44.6 (13) (24–65) | 21.0 (21) (04–38) | | Base of the tongue (189) | 81.4 (28) (74–89) | 91.1 (10) (86–97) |
*88.3 (8) (80–97) | 36.2 (103) (28–44) | 23.9 (154) (17–30) | | Posterior wall (39) |
*81.2 (6) (67–95) |
*95.5 (1) (87–100) |
*86.7 (2) (69–100) | 43.3 (19) (26–61) | 21.5 (32) (08–35) | | R status | | | | | | | R0 (64) | 80.0 (12) (70–90) | 82.2 (8) (71–94) | 91.4 (3) (82–100) | 60.9 (23) (48–74) | 47.2 (52) (35–60) | | R+ (19) | 39.4 (4) (15–65) | — (0) (—; —) | 65.5 (3) (33–98) | 23.5 (12) (01–46) | 20.1 (15) (01–40) | | |
+ | |
+ |
+ |
+ | | N category | | | | | | | N0 (115) | 83.5 (18) (76–91) |
*91.5 (6) (84–99) |
*85.7 (9) (77–95) | 57.1 (43) (47–67) | 40.3 (85) (31–50) | | N+ (303) | 80.3 (45) (74–87) | 87.2 (16) (80–94) | 81.8 (18) (73–91) | 26.9 (186) (21–33) | 14.5 (262) (10–19) | | |
+ |
+ |
+ | | | | ND (surgical therapy) | | | | | | | No (19) |
*65.9 (5) (37–93) |
*78.6 (2) (51–100) |
*— (0) (—; —) | 22.6 (13) (01–44) | 15.8 (17) (00–32) | | Yes (64) | 79.4 (11) (68–91) |
*86.0 (6) (75–97) |
*84.5 (6) (73–96) | 61.1 (22) (48–74) | 49.3 (50) (37–62) | | |
+ |
+ |
+ |
+ |
+ | | Differentiation | | | | | | | Well/moderate (264) | 82.4 (39) (77–88) | 88.8 (14) (83–95) | 82.2 (16) (73–91) | 34.1 (147) (27–41) | 20.6 (221) (16–26) | | Poor (125) | 80.7 (19) (71–90) |
*91.5 (6) (85–98) | 83.2 (10) (73–93) | 38.8 (59) (29–49) | 22.5 (102) (15–30) | | | | | | | | | Perinodal invasion | | | | | | | No (153) | 78.3 (30) (71–86) | 88.4 (11) (82–95) | 84.7 (12) (76–93) | 51.7 (62) (42–61) | 34.6 (117) (27–43) | | Yes (21) |
*65.9 (3) (62–70) |
*79.5 (2) (54–100) |
*86.3 (2) (68–100) | 19.9 (11) (01–43) | 13.2; (16) (0–29) | | |
+ |
+ |
+ |
+ |
+ | | Lymphatic invasion | | | | | | | No (164) | 79.1 (31) (72–86) | 88.2 (12) (82–95) | 84.8 (13) (77–93) | 50.8 (68) (42–60) | 33.2 (128) (26–41) | | Yes (17) |
*64.3 (3) (25–100) |
*87.5; (1) (65–100) |
*91.7; (1) (76–100) |
*30.0 (7) (00–63) | 17.9 (11) (04–39) | | |
+ |
+ |
+ |
+ |
+ | | Treatment | | | | | | | Primary surgery (83) | 74.2 (16) (63–86) |
*84.7 (8) (75–95) |
*86.5 (6) (76–97) | 52.7 (35) (41–65) | 41.2 (67) (30–52) | | Primary nonsurgical treatment (316) | 83.8 (43) (79–89) | 91.8 (11) (86–97) | 80.4 (20) (71–89) | 31.4 (184) (23–39) | 17.3; (263) (13–22) | | |
+ |
+ |
+ |
+ |
+ | | HPV | | | | | | | No (78) | 76.6 (10) (59–94) |
*97.4 (1) (93–100) |
*75.3 (6) (53–98) | 40.2 (33) (24–56) | 23.4 (52) (11–35) | | Yes (15) |
*93.3 (1) (81–100) |
*— (0) (—; —) |
*82.1 (2) (59–100) |
*64.6 (5) (40–90) |
*40.2 (9) (13–68) | | |
+ |
+ |
+ |
+ | = 0.388 |
|
|
Not enough events or patients for statistical interpretation.
+Too widely different group sizes or crossings for interpretation without a comment.
|
