Table 2
Role of PRP components in bone remodeling.
| | PDGF | Mesenchymal stem cell (MSC) and progenitor cell recruitment, proliferation, migration, and osteogenic differentiation. Osteoblast proliferation and ECM ossification [25, 128, 129] |
| | TGF- | MSC recruitment and differentiation. Increased production of collagen and mineral matrix. Inhibits osteoclast formation and bone resorption [128–130] |
| | TGF-1 | MSC recruitment, proliferation, and osteogenic differentiation [25] |
| | IGF-1 | Stimulates bone formation via cellular proliferation, differentiation, and synthesis of Type I collagen [25, 128, 129] |
| | IL-1, IL-6, TNF- | Promotes early responses of bone repair, endochondral bone formation, and bone remodeling [129, 131] |
| | Basic FGF | MSC growth and differentiation. Osteoblast proliferation [132] |
| | Fibronectin, vitronectin | Enhances formation of focal adhesions by osteoblasts, osteoblast migration [133] |
| | VEGF | Promotes angiogenesis and endochondral ossification [25] |
| | VGF, platelet microparticles | Promotes angiogenesis [131] |
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