BioMed Research International / 2014 / Article / Tab 2

Review Article

Platelet-Rich Plasma in Bone Regeneration: Engineering the Delivery for Improved Clinical Efficacy

Table 2

Role of PRP components in bone remodeling.

PDGFMesenchymal stem cell (MSC) and progenitor cell recruitment, proliferation, migration, and osteogenic differentiation. Osteoblast proliferation and ECM ossification [25, 128, 129]

TGF- MSC recruitment and differentiation. Increased production of collagen and mineral matrix. Inhibits osteoclast formation and bone resorption [128130]

TGF- 1MSC recruitment, proliferation, and osteogenic differentiation [25]

IGF-1Stimulates bone formation via cellular proliferation, differentiation, and synthesis of Type I collagen [25, 128, 129]

IL-1, IL-6, TNF- Promotes early responses of bone repair, endochondral bone formation, and bone remodeling [129, 131]

Basic FGFMSC growth and differentiation. Osteoblast proliferation [132]

Fibronectin, vitronectinEnhances formation of focal adhesions by osteoblasts, osteoblast migration [133]

VEGFPromotes angiogenesis and endochondral ossification [25]

VGF, platelet microparticlesPromotes angiogenesis [131]