Platelet-Rich Plasma in Bone Regeneration: Engineering the Delivery for Improved Clinical Efficacy

Table 4

Summary of studies that used PRP via incorporating into nanofiber matrices.

Authors	Study	Platelet concentration	Results
Berner et al. (2012) [121]	Allogenic PRP + BMP-7 + CaP coated electrospun PCL	Unknown	Significantly increased bone volume and biomechanical properties
Sell et al. (2011) [122]	PRGF scaffold characteristics and effects on human macrophages and ADSCs	955 × 10^3/𝜇L (quantified elsewhere)	Increased macrophage chemotaxis, increased proliferation, and infiltration of ADSCs. Sustained protein release discovered
Wolfe et al. (2011) [115]	PRGF scaffold characteristics and effects on human ADSCs and hSMCs	955 × 10^3/𝜇L (quantified elsewhere)	Cell integration into the scaffold after 3 days
Yoshimi et al. (2009) [119]	Self-assembling peptide “PuraMatrix” nanofiber scaffolds + PRP + dMSCs	Unknown	PRP alone did not promote bone regeneration, but it was facilitated with addition to dMSCs + PM
Kohgo et al. (2011) [120]	Osseointegration of dental implants with PM + PRP + dMSCs	Unknown	PM + dMSCs + PRP showed significant osseointegration over other groups