Nanotechnology-Applied Curcumin for Different Diseases Therapy

Table 1

Nanoparticles-conjugated curcumin characterization for different diseases treatment.

	Type of nanoparticles	Form	Size (nm)	Used models	Methods	Results	Reference
	Liposome	Globular	25–205	(i) Breast cancer; (ii) Melanoma; (iii) Renal ischemia; (iv) Malaria	In vitro; In vivo; (dog and mice)	(i) Increased solubility, tissue distribution, and stability; (ii) Enhanced antitumor and antiangiogenesis effects; (iii) Showed antimelanoma, anti-inflammatory, and antimalarial effects	[30–33]; [34–37]; [38, 39]
	Micelle	Spherical	10–100	(i) Lung tumor; (ii) Breast cancer	In vitro; In vivo; (mice)	(i) Increased solubility and bioavailability; (ii) Improved antioxidative and antitumor effects; (iii) Prolonged circulation time; (iv) Enhanced fluorescence effect	[40] [41]; [42] [43]; [44] [45]; [46]
	Noisome	Lamellar	190–1140	(i) Albino rat skin; (ii) Cancerous cells	In vitro; In vivo; (snake and mice)	(i) Increased skin penetration; (ii) Prolonged delivery system; (iii) Anti-infection and anticancer effects; (iv) Enhanced fluorescence intensity	[47] [48]; [49]
	Cyclodextrin	Cyclic	150–500	(i) Bowel disease; (ii) Breast, lung, pancreatic, and prostate cancer	In vitro; In vivo; (rat and mice)	(i) Improved solubility; (ii) Enhanced antiproliferation effects; (iii) Increased anticancer and anti-inflammatory effects; (iv) Developed bioavailability	[30]; [50–56]
	Dendrimer	Globular polymer	15–150	(i) Breast cancer; (ii) Colon cancer	In vitro; In vivo; (mice)	(i) Improved stability; (ii) Increased antitumor and antiproliferative effects	[57, 58]; [59–63]
	Nanogel	Cross-linked polymer network	10–200	(i) Melanoma; (ii) Breast and pancreatic cancer cells	In vitro	(i) Increased stability; (ii) Enhanced fluorescence effects; (iii) Developed bioavailability; (iv) Improved anticancer effects; (v) Get better controlled release; (vi) Prolonged half-life; (vii) Enhanced treatment of melanoma	[64]; [65]
	Chitosan	Linear polysaccharide composed	100–250	(i) Wounds; (ii) Melanoma tumors	In vitro; In vivo; (rat and mice)	(i) Improved chemical stability; (ii) Showed wound healing effects; (iii) Increased antitumor effects; (iv) Improved antioxidant effects; (v) Prolonged blood circulation	[66–71]
	Gold	Globular	200–250	Cancerous cells	In vitro	(i) Improved solubility; (ii) Enhanced antioxidant and anticancer effects	[72]; [73]
	Silver	Film layer	∼15	(i) Infections; (ii) Skin wounds	In vitro	(i) Showed antimicrobial effects; (ii) Improved wound healing; (iii) Increased antiviral and anticancer effects	[74]; [75]
	Solid lipid	Spherical	50–1000	(i) Cerebral ischemia; (ii) Colitis; (iii) Allergy; (iv) Breast cancer	In vitro; In vivo; (rat and mice)	(i) Prolonged circulation of blood; (ii) Increased anti-inflammatory effects; (iii) Improved brain delivery	[76–78]; [79–81]