BioMed Research International / 2014 / Article / Tab 1

Review Article

Nanotechnology-Applied Curcumin for Different Diseases Therapy

Table 1

Nanoparticles-conjugated curcumin characterization for different diseases treatment.

Type of nanoparticlesFormSize (nm)Used modelsMethodsResultsReference–205 (i) Breast cancer
(ii) Melanoma
(iii) Renal ischemia
(iv) Malaria
In vitro 
In vivo
(dog and mice)
(i) Increased solubility, tissue distribution, and stability
(ii) Enhanced antitumor and antiangiogenesis effects
(iii) Showed antimelanoma, anti-inflammatory, and antimalarial effects
[38, 39]–100 (i) Lung tumor
(ii) Breast cancer
In vitro  
In vivo
(i) Increased solubility and bioavailability
(ii) Improved antioxidative and antitumor effects
(iii) Prolonged circulation time
(iv) Enhanced fluorescence effect
[40] [41]
[42] [43]
[44] [45]
[46]–1140(i) Albino rat skin
(ii) Cancerous cells
In vitro
In vivo
(snake and mice)
(i) Increased skin penetration
(ii) Prolonged delivery system
(iii) Anti-infection and anticancer effects
(iv) Enhanced fluorescence intensity
[47] [48]
[49]–500 (i) Bowel disease
(ii) Breast, lung, pancreatic, and prostate cancer
In vitro
In vivo
(rat and mice)
(i) Improved solubility
(ii) Enhanced antiproliferation effects
(iii) Increased anticancer and anti-inflammatory effects
(iv) Developed bioavailability
[5056] polymer15–150(i) Breast cancer
(ii) Colon cancer
In vitro
In vivo
(i) Improved stability
(ii) Increased antitumor and antiproliferative effects
[57, 58]
[5963] polymer network10–200 (i) Melanoma
(ii) Breast and pancreatic cancer cells
In vitro(i) Increased stability
(ii) Enhanced fluorescence effects
(iii) Developed bioavailability
(iv) Improved anticancer effects
(v) Get better controlled release
(vi) Prolonged half-life
(vii) Enhanced treatment of melanoma
[65] Linear polysaccharide composed100–250(i) Wounds
(ii) Melanoma tumors
In vitro
In vivo
(rat and mice)
(i) Improved chemical stability
(ii) Showed wound healing effects
(iii) Increased antitumor effects
(iv) Improved antioxidant effects
(v) Prolonged blood circulation
[6671]–250 Cancerous cellsIn vitro(i) Improved solubility
(ii) Enhanced antioxidant and anticancer effects
[73] layer 15(i) Infections
(ii) Skin wounds
In vitro(i) Showed antimicrobial effects
(ii) Improved wound healing
(iii) Increased antiviral and anticancer effects
[75] lipidSpherical50–1000(i) Cerebral ischemia
(ii) Colitis
(iii) Allergy
(iv) Breast cancer
In vitro
In vivo
(rat and mice)
(i) Prolonged circulation of blood
(ii) Increased anti-inflammatory effects
(iii) Improved brain delivery

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