Gender-Specific DNA Methylome Analysis of a Han Chinese Longevity Population

Table 1

GO analysis of hypomethylated and hypermethylated DMGs.

GO ID	Description	𝑃 value	FDR
Hypomethylated genes
Biological process
GO:0016043	Cellular component organization	5.03𝐸−07	1.06𝐸−03
GO:0071840	Cellular response to vitamin A	1.74𝐸−06	1.83𝐸−03
GO:0071299	Cell surface receptor linked signaling pathway	2.27𝐸−04	2.36𝐸−02
GO:0007166	Regulation of hormone levels	3.95𝐸−04	1.36𝐸−02
GO:0010817	Cell projection organization	4.08𝐸−04	2.36𝐸−02
GO:0030030	Hormone secretion	4.96𝐸−04	2.36𝐸−02
GO:0046879	Cellular component organization at cellular level	6.80𝐸−04	4.36𝐸−02
GO:0071842	Cellular response to vitamin	6.81𝐸−04	4.36𝐸−02
GO:0071295	Regulation of transcription from RNA polymerase II promoter	7.23𝐸−04	4.36𝐸−02
GO:0006357	Epithelial cell development	8.35𝐸−04	4.59𝐸−02
GO:0002064	Hormone transport	8.52𝐸−04	4.59𝐸−02
GO:0009914	Production of molecular mediator involved in inflammatory response	8.54𝐸−04	4.59𝐸−02
GO:0002532	Cell morphogenesis involved in differentiation	8.77𝐸−04	4.59𝐸−02
GO:0000904	Transmembrane receptor protein tyrosine kinase signaling pathway	9.59𝐸−04	4.94𝐸−02
GO:0007169	Wnt receptor signaling pathway	9.71𝐸−04	4.94𝐸−02
Cellular component
GO:0015629	Actin cytoskeleton	1.94𝐸−03	4.99𝐸−02
Hypermethylated genes
Biological process
GO:0000902	Cell morphogenesis	3.23𝐸−05	3.54𝐸−02
GO:0021955	Central nervous system neuron axonogenesis	3.39𝐸−05	3.54𝐸−02
GO:0048869	cellular developmental process	4.21𝐸−05	3.54𝐸−02
GO:0032989	cellular component morphogenesis	7.81𝐸−05	3.73𝐸−02
GO:0048858	cell projection morphogenesis	8.50𝐸−05	3.73𝐸−02
GO:0032990	cell part morphogenesis	1.01𝐸−04	3.73𝐸−02
GO:0051179	localization	1.04𝐸−04	3.73𝐸−02
GO:0048667	cell morphogenesis involved in neuron differentiation	1.26𝐸−04	3.96𝐸−02
GO:0030154	cell differentiation	1.71𝐸−04	4.80𝐸−02
Cellular component
GO:0044459	plasma membrane part	1.05𝐸−05	1.99𝐸−03
GO:0016020	membrane	3.19𝐸−05	1.99𝐸−03
GO:0044425	membrane part	4.55𝐸−05	1.99𝐸−03
GO:0005911	cell-cell junction	4.67𝐸−05	2.16𝐸−03
GO:0030054	cell junction	6.34𝐸−05	4.65𝐸−03
Molecular function
GO:0015108	chloride transmembrane transporter activity	3.46𝐸−05	1.99𝐸−03
GO:0015103	inorganic anion transmembrane transporter activity	6.03𝐸−05	2.16𝐸−03
GO:0015296	anion:cationsymporter activity	1.17𝐸−04	2.65𝐸−02
GO:0004714	glycoprotein binding	1.71𝐸−04	4.80𝐸−02