Study of the Association between ITPKC Genetic Polymorphisms and Calcium Nephrolithiasis

Table 3

Association analysis of ITPKC single-nucleotide polymorphisms (SNPs) and clinical biochemical data of patients with kidney stones.

SNP	Genotype	Sample number (%)	MDRD	𝑃 value	C-G	𝑃 value
			(mL/min/1.73 m^2)		(mL/min)
rs11673492	TT	32 (8.8)	77.6±16.0	0.1471	71.4±19.2	0.2342
	CT	164 (45.1)	84.9±29.9		85.1±33.0
	CC	168 (46.1)	84.0±25.9		83.0±28.2
rs28493229	CC	0 (0.0)	—	0.5622	—	0.8885
	CG	42 (12.5)	82.9±26.4		83.2±29.3
	GG	295 (87.5)	86.9±34.3		82.1±36.7
rs7257602	GG	92 (25.3)	80.5±28.5	0.2855	77.9±29.2	0.4558
	AG	164 (45.0)	86.8±28.3		85.6±29.3
	AA	108 (29.7)	80.1±24.7		82.3±31.2
rs7251246	GG	96 (26.4)	82.5±22.4	0.0990	84.3±28.9	0.0456 *
	GA	164 (45.0)	87.6±29.9		87.4±30.7
	AA	104 (28.6)	76.7±27.3		73.2±28.3
rs890934	TT	77 (21.1)	77.9±29.0	0.4380	74.4±23.3	0.1932
	GT	180 (49.3)	84.5±28.9		84.0±32.7
	GG	108 (29.6)	84.4±23.6		86.0±29.1
rs10420685	GG	16 (4.4)	90.9±12.5	0.2153	89.5±21.1	0.1545
	AG	126 (34.6)	86.5±26.4		87.7±31.7
	AA	222 (61.0)	80.2±28.5		78.9±29.3
rs2607420	CC	27 (7.4)	69.0±16.4	𝟎.𝟎𝟒𝟎𝟓^∗	68.6±18.2	𝟎.𝟎𝟐𝟏𝟓^∗
	CT	143 (39.3)	87.2±26.6		89.2±31.6
	TT	194 (53.3)	81.6±27.9		79.2±28.3
rs2290692	GG	93 (19.4)	83.1±22.6	0.4016	84.8±29.3	0.0784
	CG	164 (34.2)	85.8±27.9		86.7±30.8
	CC	107 (46.4)	78.9±30.9		74.1±28.5

∗Significant (𝑃<0.05) values are in bold.