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BioMed Research International
Volume 2014 (2014), Article ID 398097, 10 pages
http://dx.doi.org/10.1155/2014/398097
Research Article

ELFN1-AS1: A Novel Primate Gene with Possible MicroRNA Function Expressed Predominantly in Human Tumors

1Biomedical Center, 8 Vyborgskaja Street, Saint Petersburg 194044, Russia
2Department of Genetics and Breeding, Saint Petersburg State University, 7/9 Universitetskaya Embankment, Saint Petersburg 199034, Russia

Received 23 September 2013; Revised 24 December 2013; Accepted 27 December 2013; Published 24 February 2014

Academic Editor: Franco M. Buonaguro

Copyright © 2014 Dmitrii E. Polev et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Human gene LOC100505644 uncharacterized LOC100505644 [Homo sapiens] (Entrez Gene ID 100505644) is abundantly expressed in tumors but weakly expressed in few normal tissues. Till now the function of this gene remains unknown. Here we identified the chromosomal borders of the transcribed region and the major splice form of the LOC100505644-specific transcript. We characterised the major regulatory motifs of the gene and its splice sites. Analysis of the secondary structure of the major transcript variant revealed a hairpin-like structure characteristic for precursor microRNAs. Comparative genomic analysis of the locus showed that it originated in primates de novo. Taken together, our data indicate that human gene LOC100505644 encodes some non-protein coding RNA, likely a microRNA. It was assigned a gene symbol ELFN1-AS1 (ELFN1 antisense RNA 1 (non-protein coding)). This gene combines features of evolutionary novelty and predominant expression in tumors.