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BioMed Research International
Volume 2014, Article ID 398147, 12 pages
http://dx.doi.org/10.1155/2014/398147
Research Article

Detecting Epistatic Interactions in Metagenome-Wide Association Studies by metaBOOST

MOE Key Laboratory of Bioinformatics, Bioinformatics Division and Center for Synthetic & Systems Biology, TNLIST, Department of Automation, Tsinghua University, Beijing 100084, China

Received 14 June 2014; Accepted 14 July 2014; Published 24 July 2014

Academic Editor: Hao-Teng Chang

Copyright © 2014 Mengmeng Wu and Rui Jiang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Material and Methods. We recall the definition of epistasis and extend it for metagenomic biomarkers and then we describe the overview of our method metaBOOST and provide detailed information about each step of metaBOOST. Results. We describe the data sources for both simulation studies and real metagenomic datasets. Then, we describe the procedure of simulation studies and provide results for it. After that, we conduct real datasets studies and report the results. Conclusions and Discussion. Finally, we conclude our method and discuss some possible improvements for the future.