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BioMed Research International
Volume 2014 (2014), Article ID 401595, 10 pages
http://dx.doi.org/10.1155/2014/401595
Research Article

Adiponectin Levels Are Reduced While Markers of Systemic Inflammation and Aortic Remodelling Are Increased in Intrauterine Growth Restricted Mother-Child Couple

1Department of Woman’s and Child’s Health, Maternal Fetal Medicine Unit, University of Padua School of Medicine, Padua, Italy
2Medical and Surgical Science, University of Padua, Padua, Italy
3Clinic of Obstetrics and Gynecology, Department of Experimental Clinical and Medical Science, DISM, University of Udine, Udine, Italy
4Laboratory Medicine, University of Padua, Padua, Italy
5Maternal and Fetal Medicine Unit, Obstetrics and Gynecology, University of Padua School of Medicine, Via Giustiniani No. 3, 35128 Padua, Italy

Received 28 February 2014; Revised 13 May 2014; Accepted 4 June 2014; Published 22 June 2014

Academic Editor: Grant Drummond

Copyright © 2014 Silvia Visentin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Sankaran and P. M. Kyle, “Aetiology and pathogenesis of IUGR,” Best Practice and Research: Clinical Obstetrics and Gynaecology, vol. 23, no. 6, pp. 765–777, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. D. J. P. Barker, C. Osmond, J. Golding, D. Kuh, and M. E. J. Wadsworth, “Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease,” British Medical Journal, vol. 298, no. 6673, pp. 564–567, 1989. View at Google Scholar · View at Scopus
  3. G. Reaven, “Why a cluster is truly a cluster: insulin resistance and cardiovascular disease,” Clinical Chemistry, vol. 54, no. 5, pp. 785–787, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Deepa, K. Velmurugan, K. Arvind et al., “Serum levels of interleukin 6, C-reactive protein, vascular cell adhesion molecule 1, and monocyte chemotactic protein 1 in relation to insulin resistance and glucose intolerance—the Chennai Urban Rural Epidemiology Study (CURES),” Metabolism: Clinical and Experimental, vol. 55, no. 9, pp. 1232–1238, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Jaquet, S. Deghmoun, D. Chevenne, D. Collin, P. Czernichow, and C. Lévy-Marchal, “Dynamic change in adiposity from fetal to postnatal life is involved in the metabolic syndrome associated with reduced fetal growth,” Diabetologia, vol. 48, no. 5, pp. 849–855, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. E. Koklu, S. Kurtoglu, M. Akcakus et al., “Increased aortic intima-media thickness is related to lipid profile in newborns with intrauterine growth restriction,” Hormone Research, vol. 65, no. 6, pp. 269–275, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. M. R. Skilton, N. Evans, K. A. Griffiths, J. A. Harmer, and D. S. Celermajer, “Aortic wall thickness in newborns with intrauterine growth restriction,” The Lancet, vol. 365, no. 9469, pp. 1484–1486, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Cosmi, S. Visentin, T. Fanelli, A. J. Mautone, and V. Zanardo, “Aortic intima media thickness in fetuses and children with intrauterine growth restriction,” Obstetrics and Gynecology, vol. 114, no. 5, pp. 1109–1114, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Cinar and A. Gurlek, “Association between novel adipocytokines adiponectin, vaspin, visfatin, and thyroid: an experimental and clinical update,” Endocrine Connections, vol. 2, pp. R30–R38, 2013. View at Google Scholar
  10. M. E. Street, P. Seghini, S. Feini et al., “Changes in interleukin-6 and IGF system and their relationships in placenta and cord blood in newborns with fetal growth restriction compared with controls,” European Journal of Endocrinology, vol. 155, no. 4, pp. 567–574, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. D. R. Cottam, S. G. Mattar, E. Barinas-Mitchell et al., “The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effect of weight loss,” Obesity Surgery, vol. 14, no. 5, pp. 589–600, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. S. P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R. L. Leibel, and A. W. Ferrante Jr., “Obesity is associated with macrophage accumulation in adipose tissue,” Journal of Clinical Investigation, vol. 112, no. 12, pp. 1796–1808, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. R. F. Mortensen, “C-reactive protein, inflammation, and innate immunity,” Immunologic Research, vol. 24, no. 2, pp. 163–176, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. R. S. Ahlma, D. Prabakaran, C. Mantzoros et al., “Role of leptin in the neuroendocrine response to fasting,” Nature, vol. 382, no. 6588, pp. 250–252, 1996. View at Publisher · View at Google Scholar · View at Scopus
  15. I. S. Farooqi, G. Matarese, G. M. Lord et al., “Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency,” Journal of Clinical Investigation, vol. 110, no. 8, pp. 1093–1103, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Shehzad, W. Iqbal, O. Shehzad, and Y. S. Lee, “Adiponectin: regulation of its production and its role in human diseases,” Hormones, vol. 11, no. 1, pp. 8–20, 2012. View at Google Scholar · View at Scopus
  17. M. Kyriakakou, A. Malamitsi-Puchner, H. Militsi et al., “Leptin and adiponectin concentrations in intrauterine growth restricted and appropriate for gestational age fetuses, neonates, and their mothers,” European Journal of Endocrinology, vol. 158, no. 3, pp. 343–348, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Paladini, M. Rustico, E. Viora et al., “Fetal size charts for the Italian population. Normative curves of head, abdomen and long bones,” Prenatal Diagnosis, vol. 25, no. 6, pp. 456–464, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Koklu, S. Kurtoglu, M. Akcakus, A. Yikilmaz, A. Coskun, and T. Gunes, “Intima-media thickness of the abdominal aorta of neonate with different gestational ages,” Journal of Clinical Ultrasound, vol. 35, no. 9, pp. 491–497, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Visentin, E. Grisan, V. Zanardo et al., “Developmental programming of cardiovascular risk in intrauterine growth-restricted twin fetuses according to aortic intima thickness,” Journal of Ultrasound in Medicine, vol. 32, no. 2, pp. 279–284, 2013, Erratum in “Developmental programming of cardiovascular risk in intrauterine growth-restricted twin fetuses according to aortic intima thickness”, Journal of Ultrasound in Medicine, vol. 32, no. 3, p. 550, 2013. View at Google Scholar · View at Scopus
  21. E. Koklu, M. A. Ozturk, T. Gunes, M. Akcakus, and S. Kurtoglu, “Is increased intima-media thickness associated with preatherosclerotic changes in intrauterine growth restricted newborns?” Acta Paediatrica, vol. 96, no. 12, article 1858, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. H. C. McGill Jr., C. A. McMahan, E. E. Herderick, G. T. Malcom, R. E. Tracy, and J. P. Strong, “Origin of atherosclerosis in childhood and adolescence,” American Journal of Clinical Nutrition, vol. 72, supplement 5, pp. 1307S–1315S, 2000. View at Google Scholar · View at Scopus
  23. V. R. Lo Vasco, R. Salmaso, V. Zanardo et al., “Fetal aorta wall inflammation in ultrasound-detected aortic intima/media thickness and growth retardation,” Journal of Reproductive Immunology, vol. 91, no. 1-2, pp. 103–107, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Tintu, E. Rouwet, S. Verlohren et al., “Hypoxia induces dilated cardiomyopathy in the chick embryo: mchanism, intervention, and long-term consequences,” PLoS ONE, vol. 4, no. 4, Article ID e5155, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. A. L. Fowden, D. A. Giussani, and A. J. Forhead, “Endocrine and metabolic programming during intrauterine development,” Early Human Development, vol. 81, no. 9, pp. 723–734, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. C. N. Hales and D. J. P. Barker, “Type 2 (no insulin dependent) diabetes mellitus: the thrifty phenotype hypothesis,” Diabetologia, vol. 35, pp. 595–601, 1992. View at Google Scholar
  27. J. Kewano and R. Arora, “The role of adiponectin in obesity, diabetes, and cardiovascular disease,” Journal of the CardioMetabolic Syndrome, vol. 4, no. 1, pp. 44–49, 2009. View at Publisher · View at Google Scholar
  28. F. O. Abessolo, J. P. Ngou-Mve-Ngou, J. Mouba, A. M. Bengone, and E. Ngou-Milama, “Adiponectin in mother-and-child couple: Is there a relation with materno-foetal transfer of nutrients, obesityand risk of type 2 diabetes?” Biochimica Clinica, vol. 36, no. 4, pp. 235–239, 2012. View at Google Scholar · View at Scopus
  29. R. S. Lindsay, J. D. Walker, P. J. Havel, B. A. Hamilton, A. A. Calder, and F. D. Johnstone, “Adinopnectin is present in cord blood but is unrelated to birth weight,” Diabetes Care, vol. 26, no. 8, pp. 2244–2249, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. T. A. Bucharan and A. H. Xiang, “Gestational diabetes mellitus,” The Journal of Clinical Investigation, vol. 115, no. 3, pp. 485–491, 2005. View at Publisher · View at Google Scholar
  31. D. D. Briana and A. Malamitsi-Puchner, “Intrauterine growth restriction and adult disease: the role of adipocytokines,” European Journal of Endocrinology, vol. 160, no. 3, pp. 337–347, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Tsatsanis, V. Zacharioudaki, A. Androulidaki et al., “Adiponectin induces TNF-α and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuli,” Biochemical and Biophysical Research Communications, vol. 335, no. 4, pp. 1254–1263, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Skvarca, M. Tomazic, R. Blagus, B. Krhin, and A. Janez, “Adiponectin/leptin ratio and insulin resistance in pregnancy,” Journal of International Medical Research, vol. 41, no. 1, pp. 123–128, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. C. S. Robbins, I. Hilgendorf, G. F. Weber et al., “Local proliferation dominates lesional macrophage accumulation in atherosclerosis,” Nature Medicine, vol. 19, pp. 1166–1172, 2013. View at Publisher · View at Google Scholar
  35. T. Szasz, G. F. Bomfim, and R. C. Webb, “The influence of perivascular adipose tissue on vascular homeostasis,” Vascular Health and Risk Management, vol. 9, pp. 105–116, 2013. View at Publisher · View at Google Scholar
  36. C. Boydens, N. Maenhaut, B. Pauwels, K. Decaluwé, and J. van de Voorde, “Adipose tissue as regulator of vascular tone,” Current Hypertension Reports, vol. 14, no. 3, pp. 270–278, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Cianfarani, C. Martinez, A. Maiorana, G. Scirè, G. L. Spadoni, and S. Boemi, “Adiponectin levels are reduced in children born small for gestational age and are inversely related to postnatal catch-up growth,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 3, pp. 1346–1351, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. M. E. Street, C. Volta, M. A. Ziveri, I. Viani, and S. Bernasconi, “Markers of insulin sensitivity in placentas and cord serum of intrauterine growth-restricted newborns,” Clinical Endocrinology, vol. 71, no. 3, pp. 394–399, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. T. Kamoda, H. Saitoh, M. Saito, M. Sugiura, and A. Matsui, “Serum adiponectin concentrations in newborn infants in early postnatal life,” Pediatric Research, vol. 56, no. 5, pp. 690–693, 2004. View at Publisher · View at Google Scholar · View at Scopus
  40. A. López-Bermejo, P. Casano-Sancho, J. M. Fernández-Real et al., “Both intrauterine growth restriction and postnatal growth influence childhood serum concentrations of adiponectin,” Clinical Endocrinology, vol. 61, no. 3, pp. 339–346, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. S. O. Krechowec, M. Vickers, A. Gertler, and B. H. Breier, “Prenatal influences on leptin sensitivity and susceptibility to diet-induced obesity,” Journal of Endocrinology, vol. 189, no. 2, pp. 355–363, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. I. C. McMillen, B. S. Muhlhausler, J. A. Duffield, and B. S. J. Yuen, “Prenatal programming of postnatal obesity: fetal nutrition and the regulation of leptin synthesis and secretion before birth,” Proceedings of the Nutrition Society, vol. 63, no. 3, pp. 405–412, 2004. View at Publisher · View at Google Scholar · View at Scopus
  43. M. Pighetti, G. A. Tommaselli, A. D'Elia et al., “Maternal serum and umbilical cord blood leptin concentrations with fetal growth restriction,” Obstetrics and Gynecology, vol. 102, no. 3, pp. 535–543, 2003. View at Publisher · View at Google Scholar · View at Scopus
  44. L. Yildiz, B. Avci, and M. Ingeç, “Umbilical cord and maternal blood leptin concentrations in intrauterine growth retardation,” Clinical Chemistry and Laboratory Medicine, vol. 40, no. 11, pp. 1114–1117, 2002. View at Publisher · View at Google Scholar · View at Scopus
  45. A. Varvarigou, C. S. Mantzoros, and N. G. Beratis, “Cord blood leptin concentrations in relation to intrauterine growth,” Clinical Endocrinology, vol. 50, no. 2, pp. 177–183, 1999. View at Publisher · View at Google Scholar · View at Scopus
  46. I. Cetin, P. S. Morpurgo, T. Radaelli et al., “Fetal plasma leptin concentrations: relationship with different intrauterine growth patterns from 19 weeks to term,” Pediatric Research, vol. 48, no. 5, pp. 646–651, 2000. View at Google Scholar · View at Scopus
  47. P. S. Shekhawat, J. S. Garland, C. Shivpuri et al., “Neonatal cord blood leptin: its relationship to birth weight, body mass index, maternal diabetes, and steroids,” Pediatric Research, vol. 43, no. 3, pp. 338–343, 1998. View at Google Scholar · View at Scopus
  48. A. Buchbinder, U. Lang, R. S. Baker, J. C. Khoury, J. Mershon, and K. E. Clark, “Leptin in the ovine fetus correlates with fetal and placental size,” American Journal of Obstetrics and Gynecology, vol. 185, no. 4, pp. 786–791, 2001. View at Publisher · View at Google Scholar · View at Scopus
  49. A. Tzschoppe, E. Struwe, W. Rascher et al., “Intrauterine growth restriction (IUGR) is associated with increased leptin synthesis and binding capability in neonates,” Clinical Endocrinology, vol. 74, no. 4, pp. 459–466, 2011. View at Publisher · View at Google Scholar · View at Scopus
  50. J. C. Pickup, G. D. Chusney, S. M. Thomas, and D. Burt, “Plasma interleukin-6, tumour necrosis factor α and blood cytokine production in type 2 diabetes,” Life Sciences, vol. 67, no. 3, pp. 291–300, 2000. View at Publisher · View at Google Scholar · View at Scopus
  51. S.-L. Opsjon, R. Austgulen, and A. Waage, “Interleukin-1, interleukin-6 and tumor necrosis factor at delivery in preeclamptic disorders,” Acta Obstetricia et Gynecologica Scandinavica, vol. 74, no. 1, pp. 19–26, 1995. View at Google Scholar · View at Scopus
  52. R. A. Ødegård, L. J. Vatten, S. T. Nilsen, K. Å. Salvesen, H. Vefring, and R. Austgulen, “Umbilical cord plasma interleukin-6 and fetal growth restriction in preeclampsia: a prospective study in Norway,” Obstetrics and Gynecology, vol. 98, no. 2, pp. 289–294, 2001. View at Publisher · View at Google Scholar · View at Scopus
  53. J.-M. Fernández-Real and W. Ricart, “Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/phenotype to thriftiness,” Diabetologia, vol. 42, no. 11, pp. 1367–1374, 1999. View at Publisher · View at Google Scholar · View at Scopus