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BioMed Research International
Volume 2014, Article ID 404680, 17 pages
Review Article

Effect of Antioxidants Supplementation on Aging and Longevity

1Department of Biochemistry and Cell Biology, University of Rzeszów, Zelwerowicza Street 4, 35-601 Rzeszów, Poland
2Department of Molecular Biophysics, University of Łódź, Pomorska 141/143, 90-236 Łódź, Poland

Received 14 January 2014; Accepted 11 February 2014; Published 25 March 2014

Academic Editor: Efstathios S. Gonos

Copyright © 2014 Izabela Sadowska-Bartosz and Grzegorz Bartosz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


If aging is due to or contributed by free radical reactions, as postulated by the free radical theory of aging, lifespan of organisms should be extended by administration of exogenous antioxidants. This paper reviews data on model organisms concerning the effects of exogenous antioxidants (antioxidant vitamins, lipoic acid, coenzyme Q, melatonin, resveratrol, curcumin, other polyphenols, and synthetic antioxidants including antioxidant nanoparticles) on the lifespan of model organisms. Mechanisms of effects of antioxidants, often due to indirect antioxidant action or to action not related to the antioxidant properties of the compounds administered, are discussed. The legitimacy of antioxidant supplementation in human is considered.