|
Organism | Additive | Parameter studied | Effect reported | Reference |
|
Saccharomyces cerevisiae, budding yeast | Ascorbic acid | Replicative lifespan of SOD-1 deficient mutant | Partial restoration of normal replicative lifespan | [128] |
|
Saccharomyces cerevisiae | Erythroascorbic acid | Replicative lifespan of wild-type yeast | Little effect | [24] |
|
Saccharomyces cerevisiae | α-tocopherol, CoQ alone, or with α-tocopherol | Replicative lifespan | Decrease increased oxidative stress | [24] |
|
Paramecium tetraurelia | Vitamin E | Clonal lifespan | Increase maximal (382 versus 256 fissions) at 1000 mg/L medium | [129] |
|
Paramecium tetraurelia | Melatonin | Clonal lifespan | | [130] |
|
Asplanchna brightwellii,rotifer | Vitamin E (25 ug/mL) | Lifespan | Increase limited to the prereproductive stage [15] | [131] |
|
Philodina acuticornis odiosa, rotifer | Indolepropionamide | Lifespan | Increase up to 3-fold | [13] |
|
Caenorhabditis elegans, nematode | CoQ Vitamin E | Lifespan | Prolongation | [132] |
|
Caenorhabditis elegans | 200 g/mL vitamin E from hatching to day 3 | Survival | Increase (17–23%) | [133] |
|
Caenorhabditis elegans | -Tocopherol | Lifespan | Slight extension, no effect of -tocopherol | [134] |
|
Caenorhabditis elegans | -, or -tocopherol | Lifespan | No effect | [134] |
|
Caenorhabditis elegans | Polydatin, resveratrol-3-O--mono-D-glucoside | Mean lifespan | Increase by up to 31% and 62% under normal and acute stress conditions, respectively | [56] |
|
Caenorhabditis elegans | Curcumin | Lifespan | Increase in mev-1 and daf-16 mutants | [135] |
|
Caenorhabditis elegans | Quercetin, isorhamnetin, and tamarixetin | Lifespan | Increase by 11–16% | [136] |
|
Caenorhabditis elegans | Quercetin-3-O-glucoside | Lifespan | Increase by low concentrations, decrease by high concentrations | [137] |
|
Caenorhabditis elegans | Myricetin, quercetin, kaempferol, and naringenin | Lifespan | Increase | [90] |
|
Caenorhabditis elegans | Caffeic acid, and rosmarinic acid | Lifespan | Increase | [138] |
|
Caenorhabditis elegans | Catechin | Mean lifespan, median lifespan | Increase by 9 and 13%, respectively, at 200 M | [86] |
|
Caenorhabditis elegans | (−)-Epicatechin | Lifespan | No effect | [87] |
|
Caenorhabditis elegans | Epigallocatechin gallate (220 nM) | Mean lifespan | Increase by 10% | [139] |
|
Caenorhabditis elegans | Epigallocatechin gallate | Mean lifespan | Increase under stress conditions but not under normal conditions |
[140] |
|
Caenorhabditis elegans | Ferulsinaic acid (0.5–100 M) | Lifespan | Increase | [141] |
|
Caenorhabditis elegans | Procyanidins from apples (Malus pumila,65 g/mL) | Mean lifespan | Increase | [87] |
|
Caenorhabditis elegans | Tyrosol | Lifespan | Increase | [21] |
|
Caenorhabditis elegans | Mn-N,N′-bis(salicylidene) ethylenediamide chloride (EUK-8), an SOD mimetic | Lifespan | Extension but only after specific culture conditions | [142] |
|
Caenorhabditis elegans | KPG-7, a herb complex | Lifespan | Prolongation | [143] |
|
Caenorhabditis elegans | EGb 761, extract of Ginkgo biloba leaves | Mean lifespan | Prolongation | [94] |
|
Caenorhabditis elegans | Royal gelly | Lifespan | Prolongation | [34] |
|
Caenorhabditis elegans | Pt nanoparticles (a SOD/CAT mimetic) | Lifespan | Prolongation | [31] |
|
Drosophila melanogaster | Lipoic acid | Lifespan | Increase | [144] |
|
Drosophila melanogaster | Melatonin | Lifespan | Increase | [145] |
|
Drosophila melanogaster | Epitalon | Lifespan | Increase by 11–16% | [14] |
|
Drosophila melanogaster | Carnosine | Average lifespan | Increase in males, no effect on females | [15] |
|
Drosophila melanogaster | S,S-Trolox-carnosine | Average lifespan | Increase in males (by 16%) and in females (by 36%) | [15] |
|
Drosophila melanogaster | Curcumin, 1 mg/g of medium | Lifespan | Increase | [146] |
|
Drosophila melanogaster | Curcumin, 0.5 and 1.0 mg/g | Lifespan | Increase by 6% and 26% in females and by 16% and 13% in males | [65] |
|
Drosophila melanogaster | Curcumin | Lifespan | Extension, gender- and genotype-specific | [64] |
|
Drosophila melanogaster | Aloe vera extract | Lifespan | Extension | [147] |
|
Drosophila melanogaster | Extract of black rice | Lifespan |
Increase by ca 14% | [89] |
|
Drosophila melanogaster | Cacao | Lifespan | Increase | [88] |
|
Drosophila melanogaster | Black tea extract | Mean lifespan | Increase by 10% | [148] |
|
Drosophila melanogaster | EUK-8 Mn 3-methoxy-N,N′-bis(salicyldene) ethylenediamine chloride (EUK-134), mitoquinone | Lifespan | No effect on wild type flies | [149] |
|
Anastrepha ludens, Mexican fruit fly | -, or -Tocopherol | Lifespan | No effect | [134] |
|
Mus musculus, mouse, strain C57BL/6 | Vitamin E, lifelong | Median lifespan | Increase by 15% | [150] |
|
Mus musculus | Vitamin E | Lifespan | No effect | [151] |
|
Mus musculus, C3H/He and LAF1 | Vitamin E, 0.25% w/w | Lifespan | Increase in mean lifespan, no effect on maximum lifespan | [152] |
|
Mus musculus, SAMP8 (senescence-acceleration prone) | Lipoic acid | Lifespan | Decrease | [45] |
|
Mus musculus, SAMP8 | Melatonin | Lifespan | Increase | [153] |
|
Mus musculus | Tetrahydrocurcumin, 0.2% from the age of 13 m | Average lifespan | Increase | [20] |
|
Mus musculus, males from the age of 12 m | LGcombo, complex mixture of botanical extracts, vitamins, and nutraceuticals | Lifespan | No effect | [33] |
|
Mus musculus | A fullerene mimetic of SOD | Lifespan | Prolongation | [32] |
|
Mus musculus | Royal gelly | Lifespan | Increased mean lifespan, no effect on maximal lifespan | [35] |
|
Rattus rattus, rat, Wistar | Epigallocatechin gallate | Median lifespan | Increase by 8–12 weeks (control: 105 weeks) | [77] |
|
Microtus agrestis, field vole | Vitamin C or vitamin E, for 9 m | Lifespan | Decrease | [28] |
|
Mus musculus, Ellobius talpinus (mole vole), Phodopus campbelli (dwarf hamster) | SkQ1 (mitochondrially targeted plastoquinone derivative) | Survival | Increase | [23] |
|