Table 1: Effect of supplementation with natural and synthetic antioxidants on the lifespan of model organisms.

OrganismAdditiveParameter studiedEffect reportedReference

Saccharomyces cerevisiae, budding yeastAscorbic acidReplicative lifespan of SOD-1 deficient mutantPartial restoration of normal replicative lifespan[128]

Saccharomyces cerevisiae Erythroascorbic acidReplicative lifespan of wild-type yeastLittle effect[24]

Saccharomyces cerevisiae α-tocopherol, CoQ alone, or with α-tocopherolReplicative lifespanDecrease increased oxidative stress[24]

Paramecium tetraurelia Vitamin EClonal lifespanIncrease maximal (382 versus 256 fissions) at 1000 mg/L medium[129]

Paramecium tetraurelia MelatoninClonal lifespan[130]

Asplanchna brightwellii,rotiferVitamin E (25 ug/mL)LifespanIncrease limited to the prereproductive stage [15][131]

Philodina acuticornis odiosa, rotiferIndolepropionamideLifespanIncrease up to 3-fold[13]

Caenorhabditis elegans, nematodeCoQ
Vitamin E
LifespanProlongation[132]

Caenorhabditis elegans 200  g/mL vitamin E from hatching to day 3SurvivalIncrease (17–23%)[133]

Caenorhabditis elegans -TocopherolLifespanSlight extension, no effect of -tocopherol[134]

Caenorhabditis elegans -, or -tocopherolLifespanNo effect[134]

Caenorhabditis elegans Polydatin, resveratrol-3-O- -mono-D-glucosideMean lifespanIncrease by up to 31% and 62% under normal and acute stress conditions, respectively [56]

Caenorhabditis elegans CurcuminLifespanIncrease in mev-1 and daf-16 mutants[135]

Caenorhabditis elegans Quercetin,
isorhamnetin, and tamarixetin
LifespanIncrease by 11–16%[136]

Caenorhabditis elegans Quercetin-3-O-glucosideLifespanIncrease by low concentrations, decrease by high concentrations[137]

Caenorhabditis elegans Myricetin,
quercetin, kaempferol, and naringenin
LifespanIncrease[90]

Caenorhabditis elegans Caffeic acid, and
rosmarinic acid
LifespanIncrease[138]

Caenorhabditis elegans CatechinMean lifespan, median lifespan Increase by 9 and 13%, respectively, at 200  M[86]

Caenorhabditis elegans (−)-EpicatechinLifespan No effect[87]

Caenorhabditis elegans Epigallocatechin gallate (220 nM)Mean lifespan Increase by 10%[139]

Caenorhabditis elegans Epigallocatechin gallateMean lifespanIncrease under stress conditions but not under normal conditions [140]

Caenorhabditis elegans Ferulsinaic acid (0.5–100  M)Lifespan Increase[141]

Caenorhabditis elegans Procyanidins from apples (Malus pumila,65  g/mL)Mean lifespanIncrease[87]

Caenorhabditis elegans TyrosolLifespanIncrease[21]

Caenorhabditis elegans Mn-N,N′-bis(salicylidene)
ethylenediamide chloride (EUK-8), an SOD mimetic
Lifespan Extension but only after specific culture conditions[142]

Caenorhabditis elegans KPG-7, a herb complexLifespanProlongation[143]

Caenorhabditis elegans EGb 761, extract of Ginkgo  biloba leavesMean lifespanProlongation[94]

Caenorhabditis elegans Royal gellyLifespanProlongation[34]

Caenorhabditis elegans Pt nanoparticles (a SOD/CAT mimetic)LifespanProlongation[31]

Drosophila melanogaster Lipoic acidLifespanIncrease[144]

Drosophila melanogaster MelatoninLifespanIncrease[145]

Drosophila melanogaster EpitalonLifespanIncrease by 11–16%[14]

Drosophila melanogaster CarnosineAverage lifespanIncrease in males, no effect on females[15]

Drosophila melanogaster S,S-Trolox-carnosineAverage lifespanIncrease in males (by 16%) and in females (by 36%)[15]

Drosophila melanogaster Curcumin, 1 mg/g of mediumLifespanIncrease[146]

Drosophila melanogaster Curcumin, 0.5 and 1.0 mg/gLifespanIncrease by 6% and 26% in females and by 16% and 13% in males[65]

Drosophila melanogaster CurcuminLifespanExtension, gender- and genotype-specific[64]

Drosophila melanogaster Aloe vera extractLifespan Extension[147]

Drosophila melanogaster Extract of black riceLifespan Increase by ca 14%[89]

Drosophila melanogaster CacaoLifespanIncrease[88]

Drosophila melanogaster Black tea extractMean lifespanIncrease by 10%[148]

Drosophila melanogaster EUK-8
Mn 3-methoxy-N,N′-bis(salicyldene)
ethylenediamine chloride (EUK-134), mitoquinone
LifespanNo effect on wild type flies[149]

Anastrepha ludens, Mexican fruit fly -, or -TocopherolLifespanNo effect[134]

Mus musculus, mouse, strain C57BL/6Vitamin E, lifelongMedian lifespan Increase by 15%[150]

Mus musculus Vitamin ELifespanNo effect[151]

Mus musculus, C3H/He and LAF1Vitamin E, 0.25% w/wLifespan Increase in mean lifespan, no effect on maximum lifespan[152]

Mus musculus, SAMP8 (senescence-acceleration prone) Lipoic acidLifespanDecrease[45]

Mus musculus, SAMP8MelatoninLifespanIncrease[153]

Mus musculus Tetrahydrocurcumin, 0.2% from the age of 13 mAverage lifespanIncrease[20]

Mus musculus, males from the age of 12 mLGcombo, complex mixture of botanical extracts, vitamins, and nutraceuticals LifespanNo effect[33]

Mus musculus A fullerene mimetic of SODLifespanProlongation[32]

Mus musculus Royal gellyLifespanIncreased mean lifespan, no effect on maximal lifespan[35]

Rattus rattus, rat, WistarEpigallocatechin gallateMedian lifespan Increase by 8–12 weeks (control: 105 weeks)[77]

Microtus agrestis, field voleVitamin C or vitamin E, for 9 mLifespanDecrease[28]

Mus musculus, Ellobius talpinus (mole vole),
Phodopus campbelli (dwarf hamster)
SkQ1 (mitochondrially targeted plastoquinone derivative)SurvivalIncrease[23]