Table 1: Advantages of topical delivery of ACE.

(i) Avoidance of hepatic first-pass metabolism
(ii) Accessibility to the site of action
(iii) Prevention of naive cells from toxic drugs conc.
(iv) Discontinuation on desire
(v) Drug delivery at controlled rate
(vi) Fixed plasma drug levels (transdermal delivery)
(vii) Economic benefits
(viii) Patient compliance