Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 408683, 10 pages
http://dx.doi.org/10.1155/2014/408683
Research Article

Microarray Analysis of Serum mRNA in Patients with Head and Neck Squamous Cell Carcinoma at Whole-Genome Scale

1Department of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Charles University, University Hospital Motol, Institute of Postgraduate Medicine, V Uvalu 84, 15006 Prague 5, Czech Republic
2Academy of Sciences of the Czech Republic, Institute of Molecular Genetics, Department of Genomics and Bioinformatics, Videnska 1083, 14220 Prague 4, Czech Republic
3Institute of Anatomy, 1st Faculty of Medicine, Charles University, U Nemocnice 3, 12800 Prague 2, Czech Republic
4Department of Stomatology, 1st Faculty of Medicine, Charles University, Kateřinská 32, 12108 Prague 2, Czech Republic

Received 17 January 2014; Accepted 24 February 2014; Published 23 April 2014

Academic Editor: Jan Betka

Copyright © 2014 Markéta Čapková et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table S1: List of deregulated genes in serum of cancer patients in comparison to serum of healthy individuals (p < 0.05, logFC ≥ 1).

Supplementary Table S2: List of deregulated genes in serum of treated patients in comparison to serum of healthy individuals (p < 0.05, logFC ≥ 1).

Supplementary Table S3: List of deregulated KEGG pathways in serum of cancer patients in comparison to healthy individuals ( Nsig number of significantly changed genes in the pathway; Npath number of genes in the pathway).

Supplementary Table S4: GSEA on GO terms - biological process of serum specimens of cancer patients in comparison to healthy individuals shows significant deregulation in translational processes, ribosomal biogenesis, viral transcription, negative regulation of DNA damage response - signal transduction by p53 class mediator, induction of apoptosis (showed only GO terms with p-value < 0.05).

Supplementary Table S5: GSEA on GO terms - cytological compartment of serum specimens of cancer patients in comparison to healthy individuals shows changes mainly in cytosolic or nuclear compartment (showed only GO terms with p-value < 0.05).

  1. Supplementary Tables